Advanced imaging for glaucoma study: Design, baseline characteristics, and inter-site comparison

Phuc V. Le, Xinbo Zhang, Brian A. Francis, Rohit Varma, David S. Greenfield, Joel S. Schuman, Nils Loewen, David Huang

Research output: Contribution to journalArticle

16 Citations (Scopus)

Abstract

Purpose To report the baseline characteristics of the participants in the Advanced Imaging for Glaucoma Study. To compare the participating sites for variations among subjects and the performance of imaging instruments. Design Multicenter longitudinal observational cohort study. Methods A total of 788 participants (1329 eyes) were enrolled from 3 academic referral centers. There were 145 participants (289 eyes) in the normal group, 394 participants (663 eyes) in the glaucoma suspect/preperimetric glaucoma group, and 249 participants (377 eyes) in the perimetric glaucoma group. Participants underwent a full clinical examination, standard automated perimetry, and imaging with time-domain and Fourier-domain optical coherence tomography (OCT), scanning laser polarimetry, and confocal scanning laser ophthalmoscopy. The baseline average, population standard deviation, and repeatability of imaging-derived anatomic variables were reported for each technology and center. Results Compared to the normal participants, glaucoma suspect/preperimetric glaucoma and perimetric glaucoma groups had significantly reduced anatomic measurements. Repeatability of nerve fiber layer thickness was best for Fourier-domain OCT (overall coefficient of variation

Original languageEnglish (US)
Pages (from-to)393-403.e2
JournalAmerican Journal of Ophthalmology
Volume159
Issue number2
DOIs
StatePublished - Feb 1 2015

Fingerprint

Glaucoma
Ocular Hypertension
Optical Coherence Tomography
Scanning Laser Polarimetry
Ophthalmoscopy
Visual Field Tests
Nerve Fibers
Observational Studies
Lasers
Cohort Studies
Referral and Consultation
Technology
Population

ASJC Scopus subject areas

  • Ophthalmology

Cite this

Advanced imaging for glaucoma study : Design, baseline characteristics, and inter-site comparison. / Le, Phuc V.; Zhang, Xinbo; Francis, Brian A.; Varma, Rohit; Greenfield, David S.; Schuman, Joel S.; Loewen, Nils; Huang, David.

In: American Journal of Ophthalmology, Vol. 159, No. 2, 01.02.2015, p. 393-403.e2.

Research output: Contribution to journalArticle

Le, Phuc V. ; Zhang, Xinbo ; Francis, Brian A. ; Varma, Rohit ; Greenfield, David S. ; Schuman, Joel S. ; Loewen, Nils ; Huang, David. / Advanced imaging for glaucoma study : Design, baseline characteristics, and inter-site comparison. In: American Journal of Ophthalmology. 2015 ; Vol. 159, No. 2. pp. 393-403.e2.
@article{c200fc3209474fc8a95a254d9e55212d,
title = "Advanced imaging for glaucoma study: Design, baseline characteristics, and inter-site comparison",
abstract = "Purpose To report the baseline characteristics of the participants in the Advanced Imaging for Glaucoma Study. To compare the participating sites for variations among subjects and the performance of imaging instruments. Design Multicenter longitudinal observational cohort study. Methods A total of 788 participants (1329 eyes) were enrolled from 3 academic referral centers. There were 145 participants (289 eyes) in the normal group, 394 participants (663 eyes) in the glaucoma suspect/preperimetric glaucoma group, and 249 participants (377 eyes) in the perimetric glaucoma group. Participants underwent a full clinical examination, standard automated perimetry, and imaging with time-domain and Fourier-domain optical coherence tomography (OCT), scanning laser polarimetry, and confocal scanning laser ophthalmoscopy. The baseline average, population standard deviation, and repeatability of imaging-derived anatomic variables were reported for each technology and center. Results Compared to the normal participants, glaucoma suspect/preperimetric glaucoma and perimetric glaucoma groups had significantly reduced anatomic measurements. Repeatability of nerve fiber layer thickness was best for Fourier-domain OCT (overall coefficient of variation",
author = "Le, {Phuc V.} and Xinbo Zhang and Francis, {Brian A.} and Rohit Varma and Greenfield, {David S.} and Schuman, {Joel S.} and Nils Loewen and David Huang",
year = "2015",
month = "2",
day = "1",
doi = "10.1016/j.ajo.2014.11.010",
language = "English (US)",
volume = "159",
pages = "393--403.e2",
journal = "American Journal of Ophthalmology",
issn = "0002-9394",
publisher = "Elsevier USA",
number = "2",

}

TY - JOUR

T1 - Advanced imaging for glaucoma study

T2 - Design, baseline characteristics, and inter-site comparison

AU - Le, Phuc V.

AU - Zhang, Xinbo

AU - Francis, Brian A.

AU - Varma, Rohit

AU - Greenfield, David S.

AU - Schuman, Joel S.

AU - Loewen, Nils

AU - Huang, David

PY - 2015/2/1

Y1 - 2015/2/1

N2 - Purpose To report the baseline characteristics of the participants in the Advanced Imaging for Glaucoma Study. To compare the participating sites for variations among subjects and the performance of imaging instruments. Design Multicenter longitudinal observational cohort study. Methods A total of 788 participants (1329 eyes) were enrolled from 3 academic referral centers. There were 145 participants (289 eyes) in the normal group, 394 participants (663 eyes) in the glaucoma suspect/preperimetric glaucoma group, and 249 participants (377 eyes) in the perimetric glaucoma group. Participants underwent a full clinical examination, standard automated perimetry, and imaging with time-domain and Fourier-domain optical coherence tomography (OCT), scanning laser polarimetry, and confocal scanning laser ophthalmoscopy. The baseline average, population standard deviation, and repeatability of imaging-derived anatomic variables were reported for each technology and center. Results Compared to the normal participants, glaucoma suspect/preperimetric glaucoma and perimetric glaucoma groups had significantly reduced anatomic measurements. Repeatability of nerve fiber layer thickness was best for Fourier-domain OCT (overall coefficient of variation

AB - Purpose To report the baseline characteristics of the participants in the Advanced Imaging for Glaucoma Study. To compare the participating sites for variations among subjects and the performance of imaging instruments. Design Multicenter longitudinal observational cohort study. Methods A total of 788 participants (1329 eyes) were enrolled from 3 academic referral centers. There were 145 participants (289 eyes) in the normal group, 394 participants (663 eyes) in the glaucoma suspect/preperimetric glaucoma group, and 249 participants (377 eyes) in the perimetric glaucoma group. Participants underwent a full clinical examination, standard automated perimetry, and imaging with time-domain and Fourier-domain optical coherence tomography (OCT), scanning laser polarimetry, and confocal scanning laser ophthalmoscopy. The baseline average, population standard deviation, and repeatability of imaging-derived anatomic variables were reported for each technology and center. Results Compared to the normal participants, glaucoma suspect/preperimetric glaucoma and perimetric glaucoma groups had significantly reduced anatomic measurements. Repeatability of nerve fiber layer thickness was best for Fourier-domain OCT (overall coefficient of variation

UR - http://www.scopus.com/inward/record.url?scp=84919807850&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84919807850&partnerID=8YFLogxK

U2 - 10.1016/j.ajo.2014.11.010

DO - 10.1016/j.ajo.2014.11.010

M3 - Article

C2 - 25447111

AN - SCOPUS:84919807850

VL - 159

SP - 393-403.e2

JO - American Journal of Ophthalmology

JF - American Journal of Ophthalmology

SN - 0002-9394

IS - 2

ER -