Adrenal steroid responses to continuous intravenous adrenocorticotropin infusion compared to bolus injection in normal volunteers

A. K. Munabi, P. Feuillan, R. C. Staton, D. Rodbard, G. P. Chrousos, R. E. Anderson, M. D. Strober, Donald (Lynn) Loriaux, G. B. Cutler

Research output: Contribution to journalArticle

12 Citations (Scopus)

Abstract

We compared the adrenal steroid responses after synthetic ACTH-(1-24) (Cyosyntropin) administration given by either continuous iv infusion or bolus injection in 11 normal women and 6 normal men. Each subject received 250 μg Cosyntropin as a bolus iv injection on 1 occasion and as a continuous 2-h iv infusion on another occasion, in random order. There was a 1-week interval between the studies. We measured the plasma levels of cortisol, 11-deoxycortisol, 17-hydroxyprogesterone, progesterone, pregnenolone, 17-hydroxypregnenolone, dehydroepiandrosterone, dehydroepiandrosterone sulfate, Δ5-androstenediol, androstenedione, and testosterone by RIA 15 and 0 min before and 30, 45, 60, and 120 min after administering ACTH. The steroid concentrations and their increments, ratios, or areas above baseline did differ significantly between the bolus injection and the continuous infusion. Thus, at the dose of 250 μg, a bolus ACTH injection stimulates adrenal steroid secretion as effectively as a 2-h continuous ACTH infusion.

Original languageEnglish (US)
Pages (from-to)1036-1040
Number of pages5
JournalJournal of Clinical Endocrinology and Metabolism
Volume63
Issue number4
StatePublished - 1986
Externally publishedYes

Fingerprint

Intravenous Infusions
Adrenocorticotropic Hormone
Cosyntropin
Healthy Volunteers
Steroids
Injections
17-alpha-Hydroxypregnenolone
Androstenediol
Cortodoxone
17-alpha-Hydroxyprogesterone
Pregnenolone
Dehydroepiandrosterone Sulfate
Dehydroepiandrosterone
Androstenedione
Progesterone
Hydrocortisone
Testosterone
Plasmas

ASJC Scopus subject areas

  • Biochemistry
  • Endocrinology, Diabetes and Metabolism

Cite this

Munabi, A. K., Feuillan, P., Staton, R. C., Rodbard, D., Chrousos, G. P., Anderson, R. E., ... Cutler, G. B. (1986). Adrenal steroid responses to continuous intravenous adrenocorticotropin infusion compared to bolus injection in normal volunteers. Journal of Clinical Endocrinology and Metabolism, 63(4), 1036-1040.

Adrenal steroid responses to continuous intravenous adrenocorticotropin infusion compared to bolus injection in normal volunteers. / Munabi, A. K.; Feuillan, P.; Staton, R. C.; Rodbard, D.; Chrousos, G. P.; Anderson, R. E.; Strober, M. D.; Loriaux, Donald (Lynn); Cutler, G. B.

In: Journal of Clinical Endocrinology and Metabolism, Vol. 63, No. 4, 1986, p. 1036-1040.

Research output: Contribution to journalArticle

Munabi, AK, Feuillan, P, Staton, RC, Rodbard, D, Chrousos, GP, Anderson, RE, Strober, MD, Loriaux, DL & Cutler, GB 1986, 'Adrenal steroid responses to continuous intravenous adrenocorticotropin infusion compared to bolus injection in normal volunteers', Journal of Clinical Endocrinology and Metabolism, vol. 63, no. 4, pp. 1036-1040.
Munabi, A. K. ; Feuillan, P. ; Staton, R. C. ; Rodbard, D. ; Chrousos, G. P. ; Anderson, R. E. ; Strober, M. D. ; Loriaux, Donald (Lynn) ; Cutler, G. B. / Adrenal steroid responses to continuous intravenous adrenocorticotropin infusion compared to bolus injection in normal volunteers. In: Journal of Clinical Endocrinology and Metabolism. 1986 ; Vol. 63, No. 4. pp. 1036-1040.
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