Acute myeloid leukemia: A concise review

Jennifer N. Saultz, Ramiro Garzon

Research output: Contribution to journalReview articlepeer-review

200 Scopus citations

Abstract

Acute myeloid leukemia (AML) is a heterogeneous clonal disorder characterized by immature myeloid cell proliferation and bone marrow failure. Cytogenetics and mutation testing remain a critical prognostic tool for post induction treatment. Despite rapid advances in the field including new drug targets and increased understanding of the biology, AML treatment remains unchanged for the past three decades with the majority of patients eventually relapsing and dying of the disease. Allogenic transplant remains the best chance for cure for patients with intermediate or high risk disease. In this review, we discuss the landmark genetic studies that have improved outcome prediction and novel therapies.

Original languageEnglish (US)
Article number33
JournalJournal of Clinical Medicine
Volume5
Issue number3
DOIs
StatePublished - Mar 5 2016
Externally publishedYes

Keywords

  • AML
  • Leukemia
  • Review

ASJC Scopus subject areas

  • Medicine(all)

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