Acute megakaryoblastic leukemia in Down syndrome: Orbital infiltration

Jeffrey L. Olson, Michael J. May, Linda Stork, Nina Kadan, J. Bronwyn Bateman

Research output: Contribution to journalArticlepeer-review

10 Scopus citations


PURPOSE: To describe an uncommon ocular presentation of acute megakaryoblastic leukemia in a child with Down syndrome. METHOD: Case report. Initial manifestation of disease was bilateral proptosis with secondary exposure keratitis caused by leukemic infiltration of the orbits. RESULTS: Bone marrow biopsy and immunophenotyping established the diagnosis of acute megakaryoblastic leukemia (FAB-M7). The leukemia was treated successfully with chemotherapy, with resolution of proptosis. The patient remained in remission more than 1 year after cessation of treatment. CONCLUSIONS: Bilateral proptosis can be a presenting sign of acute megakaryoblastic leukemia, a malignancy associated with Down syndrome. (C) 2000 by Elsevier Science Inc.

Original languageEnglish (US)
Pages (from-to)128-130
Number of pages3
JournalAmerican journal of ophthalmology
Issue number1
StatePublished - Jul 2000
Externally publishedYes

ASJC Scopus subject areas

  • Ophthalmology


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