Acute effects of furosemide and mannitol on central haemodynamics in the early postoperative period

Per-Olof Järnberg

Research output: Contribution to journalArticle

10 Citations (Scopus)

Abstract

The effects of furosemide and mannitol on central haemodynamics in the early postoperative period were investigated in 16 patients who had undergone upper abdominal surgery. Measurements were performed prior to, and then 10, 30, 50 and 90 min after postoperative drug administration. Furosemide administration resulted in reductions of cardiac output, mean pulmonary arterial, pulmonary capillary wedge, and mean systemic arterial pressures, while systemic vascular resistance increased. Mannitol administration on the other hand, caused increases of cardiac output, mean pulmonary arterial and pulmonary capillary wedge pressures. Systemic vascular resistance decreased. It is concluded that mannitol should be used as the diuretic of choice in the treatment of postoperative (post-traumatic) oliguria in patients without known cardiovascular disease.

Original languageEnglish (US)
Pages (from-to)184-193
Number of pages10
JournalActa Anaesthesiologica Scandinavica
Volume22
Issue number2
StatePublished - 1978
Externally publishedYes

Fingerprint

Furosemide
Mannitol
Postoperative Period
Hemodynamics
Cardiac Output
Vascular Resistance
Lung
Oliguria
Pulmonary Wedge Pressure
Diuretics
Arterial Pressure
Cardiovascular Diseases
Pharmaceutical Preparations
Therapeutics

ASJC Scopus subject areas

  • Anesthesiology and Pain Medicine

Cite this

Acute effects of furosemide and mannitol on central haemodynamics in the early postoperative period. / Järnberg, Per-Olof.

In: Acta Anaesthesiologica Scandinavica, Vol. 22, No. 2, 1978, p. 184-193.

Research output: Contribution to journalArticle

@article{bd44159220564973805290f2501061dc,
title = "Acute effects of furosemide and mannitol on central haemodynamics in the early postoperative period",
abstract = "The effects of furosemide and mannitol on central haemodynamics in the early postoperative period were investigated in 16 patients who had undergone upper abdominal surgery. Measurements were performed prior to, and then 10, 30, 50 and 90 min after postoperative drug administration. Furosemide administration resulted in reductions of cardiac output, mean pulmonary arterial, pulmonary capillary wedge, and mean systemic arterial pressures, while systemic vascular resistance increased. Mannitol administration on the other hand, caused increases of cardiac output, mean pulmonary arterial and pulmonary capillary wedge pressures. Systemic vascular resistance decreased. It is concluded that mannitol should be used as the diuretic of choice in the treatment of postoperative (post-traumatic) oliguria in patients without known cardiovascular disease.",
author = "Per-Olof J{\"a}rnberg",
year = "1978",
language = "English (US)",
volume = "22",
pages = "184--193",
journal = "Acta Anaesthesiologica Scandinavica",
issn = "0001-5172",
publisher = "Blackwell Munksgaard",
number = "2",

}

TY - JOUR

T1 - Acute effects of furosemide and mannitol on central haemodynamics in the early postoperative period

AU - Järnberg, Per-Olof

PY - 1978

Y1 - 1978

N2 - The effects of furosemide and mannitol on central haemodynamics in the early postoperative period were investigated in 16 patients who had undergone upper abdominal surgery. Measurements were performed prior to, and then 10, 30, 50 and 90 min after postoperative drug administration. Furosemide administration resulted in reductions of cardiac output, mean pulmonary arterial, pulmonary capillary wedge, and mean systemic arterial pressures, while systemic vascular resistance increased. Mannitol administration on the other hand, caused increases of cardiac output, mean pulmonary arterial and pulmonary capillary wedge pressures. Systemic vascular resistance decreased. It is concluded that mannitol should be used as the diuretic of choice in the treatment of postoperative (post-traumatic) oliguria in patients without known cardiovascular disease.

AB - The effects of furosemide and mannitol on central haemodynamics in the early postoperative period were investigated in 16 patients who had undergone upper abdominal surgery. Measurements were performed prior to, and then 10, 30, 50 and 90 min after postoperative drug administration. Furosemide administration resulted in reductions of cardiac output, mean pulmonary arterial, pulmonary capillary wedge, and mean systemic arterial pressures, while systemic vascular resistance increased. Mannitol administration on the other hand, caused increases of cardiac output, mean pulmonary arterial and pulmonary capillary wedge pressures. Systemic vascular resistance decreased. It is concluded that mannitol should be used as the diuretic of choice in the treatment of postoperative (post-traumatic) oliguria in patients without known cardiovascular disease.

UR - http://www.scopus.com/inward/record.url?scp=0017884947&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0017884947&partnerID=8YFLogxK

M3 - Article

VL - 22

SP - 184

EP - 193

JO - Acta Anaesthesiologica Scandinavica

JF - Acta Anaesthesiologica Scandinavica

SN - 0001-5172

IS - 2

ER -