Acute effects of ethanol on regional brain glucose metabolism and transport

Nora D. Volkow; Robert Hitzemann; Alfred P. Wolf; Jean Logan; Joanna S. Fowler; David Christman; Stephen L. Dewey; David Schlyer; Gale Burr; Stephen Vitkun; Jack Hirschowitz

doi:10.1016/0925-4927(90)90007-S

Acute effects of ethanol on regional brain glucose metabolism and transport

Nora D. Volkow, Robert Hitzemann, Alfred P. Wolf, Jean Logan, Joanna S. Fowler, David Christman, Stephen L. Dewey, David Schlyer, Gale Burr, Stephen Vitkun, Jack Hirschowitz

Research output: Contribution to journal › Article › peer-review

155 Scopus citations

Abstract

To evaluate the effects of ethanol in the human brain, we tested six normal subjects and six alcoholics using positron emission tomography and 2-deoxy-2-[¹⁸F]-fluoro-D-glucose (FDG) under baseline conditions and 24 hours later after ethanol administration (1 g/kg). Ethanol inhibited cortical and cerebellar glucose metabolism with relative sparing of the basal ganglia and corpus callosum. This inhibition was more pronounced in the alcoholics than in the controls. Measurement of the constants for glucose transport and utilization showed that decreased glucose metabolism was due to a reduction in glucose phosphorylation and not to a change of glucose transport into the tissue. The pattern of regional metabolic inhibition by alcohol paralleled the distribution of benzodiazepine receptors in the human brain.

Original language	English (US)
Pages (from-to)	39-48
Number of pages	10
Journal	Psychiatry Research: Neuroimaging
Volume	35
Issue number	1
DOIs	https://doi.org/10.1016/0925-4927(90)90007-S
State	Published - Apr 1990
Externally published	Yes

Keywords

Ethanol
F-fluorodeoxyglucose
benzodiazepine receptors
positron emission tomography

ASJC Scopus subject areas

Neuroscience (miscellaneous)
Radiology Nuclear Medicine and imaging
Psychiatry and Mental health

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10.1016/0925-4927(90)90007-S

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title = "Acute effects of ethanol on regional brain glucose metabolism and transport",

abstract = "To evaluate the effects of ethanol in the human brain, we tested six normal subjects and six alcoholics using positron emission tomography and 2-deoxy-2-[18F]-fluoro-D-glucose (FDG) under baseline conditions and 24 hours later after ethanol administration (1 g/kg). Ethanol inhibited cortical and cerebellar glucose metabolism with relative sparing of the basal ganglia and corpus callosum. This inhibition was more pronounced in the alcoholics than in the controls. Measurement of the constants for glucose transport and utilization showed that decreased glucose metabolism was due to a reduction in glucose phosphorylation and not to a change of glucose transport into the tissue. The pattern of regional metabolic inhibition by alcohol paralleled the distribution of benzodiazepine receptors in the human brain.",

keywords = "Ethanol, F-fluorodeoxyglucose, benzodiazepine receptors, positron emission tomography",

author = "Volkow, {Nora D.} and Robert Hitzemann and Wolf, {Alfred P.} and Jean Logan and Fowler, {Joanna S.} and David Christman and Dewey, {Stephen L.} and David Schlyer and Gale Burr and Stephen Vitkun and Jack Hirschowitz",

note = "Funding Information: Acknowledgments. This work was supported by the U.S. Department of Energy under contract DE-AC2-76Ch00016. We thank David Alexoff, Clarence Barnett, Bernard Bendriem, Robert Carciello, Prantika Som, Fritz Henn, Elizabeth Jellett, Payton King, Renee Moadel. Colleen Shea, and Don Warner for their support in various aspects of this work.",

year = "1990",

month = apr,

doi = "10.1016/0925-4927(90)90007-S",

language = "English (US)",

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pages = "39--48",

journal = "Psychiatry Research: Neuroimaging",

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AU - Volkow, Nora D.

AU - Hitzemann, Robert

AU - Wolf, Alfred P.

AU - Logan, Jean

AU - Fowler, Joanna S.

AU - Christman, David

AU - Dewey, Stephen L.

AU - Schlyer, David

AU - Burr, Gale

AU - Vitkun, Stephen

AU - Hirschowitz, Jack

N1 - Funding Information: Acknowledgments. This work was supported by the U.S. Department of Energy under contract DE-AC2-76Ch00016. We thank David Alexoff, Clarence Barnett, Bernard Bendriem, Robert Carciello, Prantika Som, Fritz Henn, Elizabeth Jellett, Payton King, Renee Moadel. Colleen Shea, and Don Warner for their support in various aspects of this work.

PY - 1990/4

Y1 - 1990/4

N2 - To evaluate the effects of ethanol in the human brain, we tested six normal subjects and six alcoholics using positron emission tomography and 2-deoxy-2-[18F]-fluoro-D-glucose (FDG) under baseline conditions and 24 hours later after ethanol administration (1 g/kg). Ethanol inhibited cortical and cerebellar glucose metabolism with relative sparing of the basal ganglia and corpus callosum. This inhibition was more pronounced in the alcoholics than in the controls. Measurement of the constants for glucose transport and utilization showed that decreased glucose metabolism was due to a reduction in glucose phosphorylation and not to a change of glucose transport into the tissue. The pattern of regional metabolic inhibition by alcohol paralleled the distribution of benzodiazepine receptors in the human brain.

AB - To evaluate the effects of ethanol in the human brain, we tested six normal subjects and six alcoholics using positron emission tomography and 2-deoxy-2-[18F]-fluoro-D-glucose (FDG) under baseline conditions and 24 hours later after ethanol administration (1 g/kg). Ethanol inhibited cortical and cerebellar glucose metabolism with relative sparing of the basal ganglia and corpus callosum. This inhibition was more pronounced in the alcoholics than in the controls. Measurement of the constants for glucose transport and utilization showed that decreased glucose metabolism was due to a reduction in glucose phosphorylation and not to a change of glucose transport into the tissue. The pattern of regional metabolic inhibition by alcohol paralleled the distribution of benzodiazepine receptors in the human brain.

KW - Ethanol

KW - F-fluorodeoxyglucose

KW - benzodiazepine receptors

KW - positron emission tomography

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Acute effects of ethanol on regional brain glucose metabolism and transport

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ASJC Scopus subject areas

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