Acute effects of ethanol on regional brain glucose metabolism and transport

Nora D. Volkow, Robert Hitzemann, Alfred P. Wolf, Jean Logan, Joanna S. Fowler, David Christman, Stephen L. Dewey, David Schlyer, Gale Burr, Stephen Vitkun, Jack Hirschowitz

Research output: Contribution to journalArticle

137 Citations (Scopus)

Abstract

To evaluate the effects of ethanol in the human brain, we tested six normal subjects and six alcoholics using positron emission tomography and 2-deoxy-2-[18F]-fluoro-D-glucose (FDG) under baseline conditions and 24 hours later after ethanol administration (1 g/kg). Ethanol inhibited cortical and cerebellar glucose metabolism with relative sparing of the basal ganglia and corpus callosum. This inhibition was more pronounced in the alcoholics than in the controls. Measurement of the constants for glucose transport and utilization showed that decreased glucose metabolism was due to a reduction in glucose phosphorylation and not to a change of glucose transport into the tissue. The pattern of regional metabolic inhibition by alcohol paralleled the distribution of benzodiazepine receptors in the human brain.

Original languageEnglish (US)
Pages (from-to)39-48
Number of pages10
JournalPsychiatry Research: Neuroimaging
Volume35
Issue number1
DOIs
StatePublished - 1990
Externally publishedYes

Fingerprint

Ethanol
Glucose
Brain
Alcoholics
Corpus Callosum
Fluorodeoxyglucose F18
GABA-A Receptors
Basal Ganglia
Positron-Emission Tomography
Phosphorylation
Alcohols

Keywords

  • F-fluorodeoxyglucose
  • benzodiazepine receptors
  • Ethanol
  • positron emission tomography

ASJC Scopus subject areas

  • Psychiatry and Mental health
  • Radiology Nuclear Medicine and imaging
  • Biological Psychiatry
  • Psychology(all)

Cite this

Volkow, N. D., Hitzemann, R., Wolf, A. P., Logan, J., Fowler, J. S., Christman, D., ... Hirschowitz, J. (1990). Acute effects of ethanol on regional brain glucose metabolism and transport. Psychiatry Research: Neuroimaging, 35(1), 39-48. https://doi.org/10.1016/0925-4927(90)90007-S

Acute effects of ethanol on regional brain glucose metabolism and transport. / Volkow, Nora D.; Hitzemann, Robert; Wolf, Alfred P.; Logan, Jean; Fowler, Joanna S.; Christman, David; Dewey, Stephen L.; Schlyer, David; Burr, Gale; Vitkun, Stephen; Hirschowitz, Jack.

In: Psychiatry Research: Neuroimaging, Vol. 35, No. 1, 1990, p. 39-48.

Research output: Contribution to journalArticle

Volkow, ND, Hitzemann, R, Wolf, AP, Logan, J, Fowler, JS, Christman, D, Dewey, SL, Schlyer, D, Burr, G, Vitkun, S & Hirschowitz, J 1990, 'Acute effects of ethanol on regional brain glucose metabolism and transport', Psychiatry Research: Neuroimaging, vol. 35, no. 1, pp. 39-48. https://doi.org/10.1016/0925-4927(90)90007-S
Volkow, Nora D. ; Hitzemann, Robert ; Wolf, Alfred P. ; Logan, Jean ; Fowler, Joanna S. ; Christman, David ; Dewey, Stephen L. ; Schlyer, David ; Burr, Gale ; Vitkun, Stephen ; Hirschowitz, Jack. / Acute effects of ethanol on regional brain glucose metabolism and transport. In: Psychiatry Research: Neuroimaging. 1990 ; Vol. 35, No. 1. pp. 39-48.
@article{a3ee4408de2d447a85517340c2d4aba4,
title = "Acute effects of ethanol on regional brain glucose metabolism and transport",
abstract = "To evaluate the effects of ethanol in the human brain, we tested six normal subjects and six alcoholics using positron emission tomography and 2-deoxy-2-[18F]-fluoro-D-glucose (FDG) under baseline conditions and 24 hours later after ethanol administration (1 g/kg). Ethanol inhibited cortical and cerebellar glucose metabolism with relative sparing of the basal ganglia and corpus callosum. This inhibition was more pronounced in the alcoholics than in the controls. Measurement of the constants for glucose transport and utilization showed that decreased glucose metabolism was due to a reduction in glucose phosphorylation and not to a change of glucose transport into the tissue. The pattern of regional metabolic inhibition by alcohol paralleled the distribution of benzodiazepine receptors in the human brain.",
keywords = "F-fluorodeoxyglucose, benzodiazepine receptors, Ethanol, positron emission tomography",
author = "Volkow, {Nora D.} and Robert Hitzemann and Wolf, {Alfred P.} and Jean Logan and Fowler, {Joanna S.} and David Christman and Dewey, {Stephen L.} and David Schlyer and Gale Burr and Stephen Vitkun and Jack Hirschowitz",
year = "1990",
doi = "10.1016/0925-4927(90)90007-S",
language = "English (US)",
volume = "35",
pages = "39--48",
journal = "Psychiatry Research - Neuroimaging",
issn = "0925-4927",
publisher = "Elsevier Ireland Ltd",
number = "1",

}

TY - JOUR

T1 - Acute effects of ethanol on regional brain glucose metabolism and transport

AU - Volkow, Nora D.

AU - Hitzemann, Robert

AU - Wolf, Alfred P.

AU - Logan, Jean

AU - Fowler, Joanna S.

AU - Christman, David

AU - Dewey, Stephen L.

AU - Schlyer, David

AU - Burr, Gale

AU - Vitkun, Stephen

AU - Hirschowitz, Jack

PY - 1990

Y1 - 1990

N2 - To evaluate the effects of ethanol in the human brain, we tested six normal subjects and six alcoholics using positron emission tomography and 2-deoxy-2-[18F]-fluoro-D-glucose (FDG) under baseline conditions and 24 hours later after ethanol administration (1 g/kg). Ethanol inhibited cortical and cerebellar glucose metabolism with relative sparing of the basal ganglia and corpus callosum. This inhibition was more pronounced in the alcoholics than in the controls. Measurement of the constants for glucose transport and utilization showed that decreased glucose metabolism was due to a reduction in glucose phosphorylation and not to a change of glucose transport into the tissue. The pattern of regional metabolic inhibition by alcohol paralleled the distribution of benzodiazepine receptors in the human brain.

AB - To evaluate the effects of ethanol in the human brain, we tested six normal subjects and six alcoholics using positron emission tomography and 2-deoxy-2-[18F]-fluoro-D-glucose (FDG) under baseline conditions and 24 hours later after ethanol administration (1 g/kg). Ethanol inhibited cortical and cerebellar glucose metabolism with relative sparing of the basal ganglia and corpus callosum. This inhibition was more pronounced in the alcoholics than in the controls. Measurement of the constants for glucose transport and utilization showed that decreased glucose metabolism was due to a reduction in glucose phosphorylation and not to a change of glucose transport into the tissue. The pattern of regional metabolic inhibition by alcohol paralleled the distribution of benzodiazepine receptors in the human brain.

KW - F-fluorodeoxyglucose

KW - benzodiazepine receptors

KW - Ethanol

KW - positron emission tomography

UR - http://www.scopus.com/inward/record.url?scp=0025371977&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0025371977&partnerID=8YFLogxK

U2 - 10.1016/0925-4927(90)90007-S

DO - 10.1016/0925-4927(90)90007-S

M3 - Article

C2 - 2164230

AN - SCOPUS:0025371977

VL - 35

SP - 39

EP - 48

JO - Psychiatry Research - Neuroimaging

JF - Psychiatry Research - Neuroimaging

SN - 0925-4927

IS - 1

ER -