Acute cerebral effects of isotonic crystalloid and colloid solutions following cryogenic brain injury in the rabbit

Mark Zornow, M. S. Scheller, M. M. Todd, S. S. Moore

Research output: Contribution to journalArticle

52 Citations (Scopus)

Abstract

Despite the numerous studies examining the relative merits of crystalloids versus colloids for expansion of intravascular volume, little attention has been directed to the cerebral effects of these solutions. In particular, the effect of changes in plasma oncotic pressure on brain water content are poorly understood. The authors recently examined the acute effects of changes in plasma osmolality and colloid oncotic pressure in normal animals, and found that a 65% reduction in oncotic pressure had no detectable effect on brain water content or intracranial pressure. In an effort to extend these studies to a more clinically relevant situation, the authors have now compared the acute effects of 0.9% saline, 6% hetastarch, and 5% albumin on regional cerebral water content and intracranial pressure in an animal model of brain injury produced by focal cortical freezing. Under general anesthesia and following the production of the cryogenic brain lesion, rabbits underwent a 45-min period of isovolemic hemodilution to a hematocrit of 20-25% with one of the three selected fluids. The saline group required approximately twice as much fluid (207 ± 17 ml) to maintain a stable mean arterial pressure and central venous pressure as did the hetastarch (105 ± 14 ml) or albumin (103 ± 29 ml) groups. As intended, the oncotic pressure decreased by a mean of 9.6 ± 2.4 mmHg in the saline group, while remaining stable in the hetastarch and albumin groups. There were no significant changes in osmolality in any group during the hemodilution period. Intracranial pressure increased in all groups following production of the cerebral lesion, but there were no differences between the various experimental groups upon conclusion of the hemodilution. Brain water content was significantly increased in the vicinity of the cryogenic lesion, but there were no differences between the various hemodilution groups. This experiment suggests that a decrease in plasma oncotic pressure due to the administration of an isotonic crystalloid solution does not acutely exacerbate the cerebral edema that is produced by this model of brain injury.

Original languageEnglish (US)
Pages (from-to)180-184
Number of pages5
JournalAnesthesiology
Volume69
Issue number2
StatePublished - 1988
Externally publishedYes

Fingerprint

Colloids
Hemodilution
Brain Injuries
Hydroxyethyl Starch Derivatives
Rabbits
Intracranial Pressure
Pressure
Albumins
Water
Brain
Osmolar Concentration
Isotonic Solutions
Central Venous Pressure
Brain Edema
Hematocrit
General Anesthesia
Freezing
Arterial Pressure
Animal Models
crystalloid solutions

ASJC Scopus subject areas

  • Anesthesiology and Pain Medicine

Cite this

Acute cerebral effects of isotonic crystalloid and colloid solutions following cryogenic brain injury in the rabbit. / Zornow, Mark; Scheller, M. S.; Todd, M. M.; Moore, S. S.

In: Anesthesiology, Vol. 69, No. 2, 1988, p. 180-184.

Research output: Contribution to journalArticle

@article{436b4c9fd35244e29a68fd5cbda58f27,
title = "Acute cerebral effects of isotonic crystalloid and colloid solutions following cryogenic brain injury in the rabbit",
abstract = "Despite the numerous studies examining the relative merits of crystalloids versus colloids for expansion of intravascular volume, little attention has been directed to the cerebral effects of these solutions. In particular, the effect of changes in plasma oncotic pressure on brain water content are poorly understood. The authors recently examined the acute effects of changes in plasma osmolality and colloid oncotic pressure in normal animals, and found that a 65{\%} reduction in oncotic pressure had no detectable effect on brain water content or intracranial pressure. In an effort to extend these studies to a more clinically relevant situation, the authors have now compared the acute effects of 0.9{\%} saline, 6{\%} hetastarch, and 5{\%} albumin on regional cerebral water content and intracranial pressure in an animal model of brain injury produced by focal cortical freezing. Under general anesthesia and following the production of the cryogenic brain lesion, rabbits underwent a 45-min period of isovolemic hemodilution to a hematocrit of 20-25{\%} with one of the three selected fluids. The saline group required approximately twice as much fluid (207 ± 17 ml) to maintain a stable mean arterial pressure and central venous pressure as did the hetastarch (105 ± 14 ml) or albumin (103 ± 29 ml) groups. As intended, the oncotic pressure decreased by a mean of 9.6 ± 2.4 mmHg in the saline group, while remaining stable in the hetastarch and albumin groups. There were no significant changes in osmolality in any group during the hemodilution period. Intracranial pressure increased in all groups following production of the cerebral lesion, but there were no differences between the various experimental groups upon conclusion of the hemodilution. Brain water content was significantly increased in the vicinity of the cryogenic lesion, but there were no differences between the various hemodilution groups. This experiment suggests that a decrease in plasma oncotic pressure due to the administration of an isotonic crystalloid solution does not acutely exacerbate the cerebral edema that is produced by this model of brain injury.",
author = "Mark Zornow and Scheller, {M. S.} and Todd, {M. M.} and Moore, {S. S.}",
year = "1988",
language = "English (US)",
volume = "69",
pages = "180--184",
journal = "Anesthesiology",
issn = "0003-3022",
publisher = "Lippincott Williams and Wilkins",
number = "2",

}

TY - JOUR

T1 - Acute cerebral effects of isotonic crystalloid and colloid solutions following cryogenic brain injury in the rabbit

AU - Zornow, Mark

AU - Scheller, M. S.

AU - Todd, M. M.

AU - Moore, S. S.

PY - 1988

Y1 - 1988

N2 - Despite the numerous studies examining the relative merits of crystalloids versus colloids for expansion of intravascular volume, little attention has been directed to the cerebral effects of these solutions. In particular, the effect of changes in plasma oncotic pressure on brain water content are poorly understood. The authors recently examined the acute effects of changes in plasma osmolality and colloid oncotic pressure in normal animals, and found that a 65% reduction in oncotic pressure had no detectable effect on brain water content or intracranial pressure. In an effort to extend these studies to a more clinically relevant situation, the authors have now compared the acute effects of 0.9% saline, 6% hetastarch, and 5% albumin on regional cerebral water content and intracranial pressure in an animal model of brain injury produced by focal cortical freezing. Under general anesthesia and following the production of the cryogenic brain lesion, rabbits underwent a 45-min period of isovolemic hemodilution to a hematocrit of 20-25% with one of the three selected fluids. The saline group required approximately twice as much fluid (207 ± 17 ml) to maintain a stable mean arterial pressure and central venous pressure as did the hetastarch (105 ± 14 ml) or albumin (103 ± 29 ml) groups. As intended, the oncotic pressure decreased by a mean of 9.6 ± 2.4 mmHg in the saline group, while remaining stable in the hetastarch and albumin groups. There were no significant changes in osmolality in any group during the hemodilution period. Intracranial pressure increased in all groups following production of the cerebral lesion, but there were no differences between the various experimental groups upon conclusion of the hemodilution. Brain water content was significantly increased in the vicinity of the cryogenic lesion, but there were no differences between the various hemodilution groups. This experiment suggests that a decrease in plasma oncotic pressure due to the administration of an isotonic crystalloid solution does not acutely exacerbate the cerebral edema that is produced by this model of brain injury.

AB - Despite the numerous studies examining the relative merits of crystalloids versus colloids for expansion of intravascular volume, little attention has been directed to the cerebral effects of these solutions. In particular, the effect of changes in plasma oncotic pressure on brain water content are poorly understood. The authors recently examined the acute effects of changes in plasma osmolality and colloid oncotic pressure in normal animals, and found that a 65% reduction in oncotic pressure had no detectable effect on brain water content or intracranial pressure. In an effort to extend these studies to a more clinically relevant situation, the authors have now compared the acute effects of 0.9% saline, 6% hetastarch, and 5% albumin on regional cerebral water content and intracranial pressure in an animal model of brain injury produced by focal cortical freezing. Under general anesthesia and following the production of the cryogenic brain lesion, rabbits underwent a 45-min period of isovolemic hemodilution to a hematocrit of 20-25% with one of the three selected fluids. The saline group required approximately twice as much fluid (207 ± 17 ml) to maintain a stable mean arterial pressure and central venous pressure as did the hetastarch (105 ± 14 ml) or albumin (103 ± 29 ml) groups. As intended, the oncotic pressure decreased by a mean of 9.6 ± 2.4 mmHg in the saline group, while remaining stable in the hetastarch and albumin groups. There were no significant changes in osmolality in any group during the hemodilution period. Intracranial pressure increased in all groups following production of the cerebral lesion, but there were no differences between the various experimental groups upon conclusion of the hemodilution. Brain water content was significantly increased in the vicinity of the cryogenic lesion, but there were no differences between the various hemodilution groups. This experiment suggests that a decrease in plasma oncotic pressure due to the administration of an isotonic crystalloid solution does not acutely exacerbate the cerebral edema that is produced by this model of brain injury.

UR - http://www.scopus.com/inward/record.url?scp=0023732707&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0023732707&partnerID=8YFLogxK

M3 - Article

C2 - 2457341

AN - SCOPUS:0023732707

VL - 69

SP - 180

EP - 184

JO - Anesthesiology

JF - Anesthesiology

SN - 0003-3022

IS - 2

ER -