Acute arsenic trioxide ant bait ingestion by toddlers

Jonathan P. Yarris, E. Martin Caravati, B (Zane) Horowitz, John R. Stromness, Barbara I. Crouch, Nathanael J. McKeown

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

Introduction. Arsenic trioxide is available for home use in ant baits. Potential arsenic toxicity from unintentional pediatric ingestion is not well studied. The goal of this study is to describe the clinical course and urinary arsenic concentrations of children who ingested ant bait containing arsenic trioxide (0.46%). Methods. This is a case series of pre-school children who unintentionally ingested arsenic trioxide ant bait gel bars in the home reported to two U.S. poison control centers from January 2003 to July 2007. Results. Six children (age range, 8 months to 4 years) ingested varying portions of ant bait gel bars containing arsenic trioxide (0.46%). All vomited shortly after exposure. The initial, pre-chelation urine total arsenic concentrations ranged from 1,858 to 13,981 mcg/L. All children had resolution of symptoms and received chelation with succimer. Follow-up urine arsenic concentrations were in the normal range 14-35 days after chelation and no further clinical toxicity was noted. Conclusions. Children who ingest all or part of a household ant bait gel bar that contains relatively low concentration of arsenic trioxide can develop markedly elevated urine arsenic concentrations with minor initial symptoms. Prompt chelation with succimer is recommended for children with these exposures and continued until urine arsenic concentrations are normal.

Original languageEnglish (US)
Pages (from-to)785-789
Number of pages5
JournalClinical Toxicology
Volume46
Issue number9
DOIs
StatePublished - Nov 2008

Fingerprint

Ants
Arsenic
Eating
Chelation
Urine
Succimer
Gels
Toxicity
Poison Control Centers
Pediatrics
Poisons
arsenic trioxide
Reference Values

Keywords

  • Arsenic trioxide
  • Pediatric
  • Pesticide

ASJC Scopus subject areas

  • Toxicology

Cite this

Yarris, J. P., Caravati, E. M., Horowitz, B. Z., Stromness, J. R., Crouch, B. I., & McKeown, N. J. (2008). Acute arsenic trioxide ant bait ingestion by toddlers. Clinical Toxicology, 46(9), 785-789. https://doi.org/10.1080/15563650802172071

Acute arsenic trioxide ant bait ingestion by toddlers. / Yarris, Jonathan P.; Caravati, E. Martin; Horowitz, B (Zane); Stromness, John R.; Crouch, Barbara I.; McKeown, Nathanael J.

In: Clinical Toxicology, Vol. 46, No. 9, 11.2008, p. 785-789.

Research output: Contribution to journalArticle

Yarris, JP, Caravati, EM, Horowitz, BZ, Stromness, JR, Crouch, BI & McKeown, NJ 2008, 'Acute arsenic trioxide ant bait ingestion by toddlers', Clinical Toxicology, vol. 46, no. 9, pp. 785-789. https://doi.org/10.1080/15563650802172071
Yarris JP, Caravati EM, Horowitz BZ, Stromness JR, Crouch BI, McKeown NJ. Acute arsenic trioxide ant bait ingestion by toddlers. Clinical Toxicology. 2008 Nov;46(9):785-789. https://doi.org/10.1080/15563650802172071
Yarris, Jonathan P. ; Caravati, E. Martin ; Horowitz, B (Zane) ; Stromness, John R. ; Crouch, Barbara I. ; McKeown, Nathanael J. / Acute arsenic trioxide ant bait ingestion by toddlers. In: Clinical Toxicology. 2008 ; Vol. 46, No. 9. pp. 785-789.
@article{76541208aea747d2bb1f1c6410b249af,
title = "Acute arsenic trioxide ant bait ingestion by toddlers",
abstract = "Introduction. Arsenic trioxide is available for home use in ant baits. Potential arsenic toxicity from unintentional pediatric ingestion is not well studied. The goal of this study is to describe the clinical course and urinary arsenic concentrations of children who ingested ant bait containing arsenic trioxide (0.46{\%}). Methods. This is a case series of pre-school children who unintentionally ingested arsenic trioxide ant bait gel bars in the home reported to two U.S. poison control centers from January 2003 to July 2007. Results. Six children (age range, 8 months to 4 years) ingested varying portions of ant bait gel bars containing arsenic trioxide (0.46{\%}). All vomited shortly after exposure. The initial, pre-chelation urine total arsenic concentrations ranged from 1,858 to 13,981 mcg/L. All children had resolution of symptoms and received chelation with succimer. Follow-up urine arsenic concentrations were in the normal range 14-35 days after chelation and no further clinical toxicity was noted. Conclusions. Children who ingest all or part of a household ant bait gel bar that contains relatively low concentration of arsenic trioxide can develop markedly elevated urine arsenic concentrations with minor initial symptoms. Prompt chelation with succimer is recommended for children with these exposures and continued until urine arsenic concentrations are normal.",
keywords = "Arsenic trioxide, Pediatric, Pesticide",
author = "Yarris, {Jonathan P.} and Caravati, {E. Martin} and Horowitz, {B (Zane)} and Stromness, {John R.} and Crouch, {Barbara I.} and McKeown, {Nathanael J.}",
year = "2008",
month = "11",
doi = "10.1080/15563650802172071",
language = "English (US)",
volume = "46",
pages = "785--789",
journal = "Clinical Toxicology",
issn = "1556-3650",
publisher = "Informa Healthcare",
number = "9",

}

TY - JOUR

T1 - Acute arsenic trioxide ant bait ingestion by toddlers

AU - Yarris, Jonathan P.

AU - Caravati, E. Martin

AU - Horowitz, B (Zane)

AU - Stromness, John R.

AU - Crouch, Barbara I.

AU - McKeown, Nathanael J.

PY - 2008/11

Y1 - 2008/11

N2 - Introduction. Arsenic trioxide is available for home use in ant baits. Potential arsenic toxicity from unintentional pediatric ingestion is not well studied. The goal of this study is to describe the clinical course and urinary arsenic concentrations of children who ingested ant bait containing arsenic trioxide (0.46%). Methods. This is a case series of pre-school children who unintentionally ingested arsenic trioxide ant bait gel bars in the home reported to two U.S. poison control centers from January 2003 to July 2007. Results. Six children (age range, 8 months to 4 years) ingested varying portions of ant bait gel bars containing arsenic trioxide (0.46%). All vomited shortly after exposure. The initial, pre-chelation urine total arsenic concentrations ranged from 1,858 to 13,981 mcg/L. All children had resolution of symptoms and received chelation with succimer. Follow-up urine arsenic concentrations were in the normal range 14-35 days after chelation and no further clinical toxicity was noted. Conclusions. Children who ingest all or part of a household ant bait gel bar that contains relatively low concentration of arsenic trioxide can develop markedly elevated urine arsenic concentrations with minor initial symptoms. Prompt chelation with succimer is recommended for children with these exposures and continued until urine arsenic concentrations are normal.

AB - Introduction. Arsenic trioxide is available for home use in ant baits. Potential arsenic toxicity from unintentional pediatric ingestion is not well studied. The goal of this study is to describe the clinical course and urinary arsenic concentrations of children who ingested ant bait containing arsenic trioxide (0.46%). Methods. This is a case series of pre-school children who unintentionally ingested arsenic trioxide ant bait gel bars in the home reported to two U.S. poison control centers from January 2003 to July 2007. Results. Six children (age range, 8 months to 4 years) ingested varying portions of ant bait gel bars containing arsenic trioxide (0.46%). All vomited shortly after exposure. The initial, pre-chelation urine total arsenic concentrations ranged from 1,858 to 13,981 mcg/L. All children had resolution of symptoms and received chelation with succimer. Follow-up urine arsenic concentrations were in the normal range 14-35 days after chelation and no further clinical toxicity was noted. Conclusions. Children who ingest all or part of a household ant bait gel bar that contains relatively low concentration of arsenic trioxide can develop markedly elevated urine arsenic concentrations with minor initial symptoms. Prompt chelation with succimer is recommended for children with these exposures and continued until urine arsenic concentrations are normal.

KW - Arsenic trioxide

KW - Pediatric

KW - Pesticide

UR - http://www.scopus.com/inward/record.url?scp=55949130622&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=55949130622&partnerID=8YFLogxK

U2 - 10.1080/15563650802172071

DO - 10.1080/15563650802172071

M3 - Article

VL - 46

SP - 785

EP - 789

JO - Clinical Toxicology

JF - Clinical Toxicology

SN - 1556-3650

IS - 9

ER -