Activation of the Sympathetic Nervous System by Galanin-Like Peptide - A Possible Link between Leptin and Metabolism

Karl R. Hansen, Stephanie Krasnow, Michael A. Nolan, Gregory S. Fraley, James W. Baumgartner, Donald K. Clifton, Robert A. Steiner

Research output: Contribution to journalArticle

65 Citations (Scopus)

Abstract

The effects of leptin upon body weight (BW) cannot be explained by its anorectic actions alone. Part of the metabolic changes elicited by leptin includes sympathetic nervous system activation leading to increased energy expenditure. Galanin-like peptide (GALP), a recently described hypothalamic neuropeptide, is up-regulated by leptin and has anorectic effects in the mouse. We postulated that GALP mediates effects of leptin upon metabolism. To test this hypothesis, we administered GALP centrally to the leptin-deficient ob/ob mouse. Acutely, GALP induced a decrease in food intake and BW, both of which remained significant relative to controls for 4 d. Chronic GALP administration resulted in a sustained decrease in BW and an increase in core body temperature, despite significant recovery of food intake. In a pair-fed model, chronic GALP treatment resulted in a greater decrease in BW than that seen in controls. Furthermore, GALP treatment resulted in increased body temperature and uncoupling protein 1 mRNA and protein in brown adipose tissue compared with controls. The expression of pro-opiomelanocortin (POMC) mRNA in the arcuate nucleus was decreased after chronic GALP treatment. These observations suggest that leptin's activation of the sympathetic nervous system, and ultimately thermogenesis, may be partially mediated by GALP through a melanocortin- independent mechanism.

Original languageEnglish (US)
Pages (from-to)4709-4717
Number of pages9
JournalEndocrinology
Volume144
Issue number11
DOIs
StatePublished - Nov 2003
Externally publishedYes

Fingerprint

Galanin-Like Peptide
Sympathetic Nervous System
Leptin
Body Weight
Appetite Depressants
Body Temperature
Eating
Melanocortins
peptide A
Pro-Opiomelanocortin
Messenger RNA
Arcuate Nucleus of Hypothalamus
Brown Adipose Tissue
Thermogenesis
Neuropeptides
Energy Metabolism

ASJC Scopus subject areas

  • Endocrinology
  • Endocrinology, Diabetes and Metabolism

Cite this

Hansen, K. R., Krasnow, S., Nolan, M. A., Fraley, G. S., Baumgartner, J. W., Clifton, D. K., & Steiner, R. A. (2003). Activation of the Sympathetic Nervous System by Galanin-Like Peptide - A Possible Link between Leptin and Metabolism. Endocrinology, 144(11), 4709-4717. https://doi.org/10.1210/en.2003-0748

Activation of the Sympathetic Nervous System by Galanin-Like Peptide - A Possible Link between Leptin and Metabolism. / Hansen, Karl R.; Krasnow, Stephanie; Nolan, Michael A.; Fraley, Gregory S.; Baumgartner, James W.; Clifton, Donald K.; Steiner, Robert A.

In: Endocrinology, Vol. 144, No. 11, 11.2003, p. 4709-4717.

Research output: Contribution to journalArticle

Hansen, KR, Krasnow, S, Nolan, MA, Fraley, GS, Baumgartner, JW, Clifton, DK & Steiner, RA 2003, 'Activation of the Sympathetic Nervous System by Galanin-Like Peptide - A Possible Link between Leptin and Metabolism', Endocrinology, vol. 144, no. 11, pp. 4709-4717. https://doi.org/10.1210/en.2003-0748
Hansen, Karl R. ; Krasnow, Stephanie ; Nolan, Michael A. ; Fraley, Gregory S. ; Baumgartner, James W. ; Clifton, Donald K. ; Steiner, Robert A. / Activation of the Sympathetic Nervous System by Galanin-Like Peptide - A Possible Link between Leptin and Metabolism. In: Endocrinology. 2003 ; Vol. 144, No. 11. pp. 4709-4717.
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