Activation of protein kinase A-independent pathways by Gsα in Drosophila

William J. Wolfgang, Ian J.H. Roberts, Frank Quan, Cahir O'Kane, Michael Forte

Research output: Contribution to journalArticlepeer-review

27 Scopus citations


One of the best-described transmembrane signal transduction mechanisms is based on receptor activation of the α subunit of the heterotrimeric G protein Gs, leading to stimulation of adenylyl cyclase and the production of cAMP. Intracellular cAMP is then thought to mediate its effects largely, if not entirely, by activation of protein kinase A and the subsequent phosphorylation of substrates which in turn control diverse cellular phenomena. In this report we demonstrate, by two different methods, that reduction or elimination of protein kinase A activity had no effect on phenotypes generated by activation of Gsα pathways in Drosophila wing epithelial cells. These genetic studies show that the Gsα pathway mediates its primary effects by a novel pathway in differentiating wing epithelial cells. This novel pathway may in part be responsible for some of the complex, cell-specific responses observed following activation of this pathway in different cell types.

Original languageEnglish (US)
Pages (from-to)14542-14547
Number of pages6
JournalProceedings of the National Academy of Sciences of the United States of America
Issue number25
StatePublished - Dec 10 1996
Externally publishedYes


  • Cell adhesion
  • Epithelial cells
  • G-protein
  • Integrins
  • Signal transduction

ASJC Scopus subject areas

  • General


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