Actions of clozapine and haloperidol on the extracellular levels of excitatory amino acids in the prefrontal cortex and striatum of conscious rats

Darron A. Daly, Bita Moghaddam

Research output: Contribution to journalArticle

106 Citations (Scopus)

Abstract

The technique of intracerebral microdialysis was employed to assess the effect of acute clozapine and haloperidol on the extracellular levels of aspartate and glutamate in the striatum and medial prefrontal cortex of conscious rats. Subcutaneous injection of 25 mg/kg clozapine, but not the lower dose of 15 mg/kg, led to a significant increase in both aspartate and glutamate levels over time. The maximum effect was observed two hours after injection. Haloperidol (0.5 and 1 mg/kg s.c.) did not increase the extracellular levels of aspartate and glutamate over time. At all doses tested, both drugs were without a significant effect in the striatum. These data suggest that clozapine may have selective actions on the cortical excitatory amino acid systems.

Original languageEnglish (US)
Pages (from-to)61-64
Number of pages4
JournalNeuroscience Letters
Volume152
Issue number1-2
DOIs
StatePublished - Apr 2 1993
Externally publishedYes

Fingerprint

Excitatory Amino Acids
Clozapine
Haloperidol
Prefrontal Cortex
Aspartic Acid
Glutamic Acid
Microdialysis
Subcutaneous Injections
Injections
Pharmaceutical Preparations

Keywords

  • Clozapine
  • Glutamate
  • Haloperidol
  • Microdialysis
  • Prefrontal cortex
  • Schizophrenia

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

@article{633aeec5027c48969649f4e55d740c4a,
title = "Actions of clozapine and haloperidol on the extracellular levels of excitatory amino acids in the prefrontal cortex and striatum of conscious rats",
abstract = "The technique of intracerebral microdialysis was employed to assess the effect of acute clozapine and haloperidol on the extracellular levels of aspartate and glutamate in the striatum and medial prefrontal cortex of conscious rats. Subcutaneous injection of 25 mg/kg clozapine, but not the lower dose of 15 mg/kg, led to a significant increase in both aspartate and glutamate levels over time. The maximum effect was observed two hours after injection. Haloperidol (0.5 and 1 mg/kg s.c.) did not increase the extracellular levels of aspartate and glutamate over time. At all doses tested, both drugs were without a significant effect in the striatum. These data suggest that clozapine may have selective actions on the cortical excitatory amino acid systems.",
keywords = "Clozapine, Glutamate, Haloperidol, Microdialysis, Prefrontal cortex, Schizophrenia",
author = "Daly, {Darron A.} and Bita Moghaddam",
year = "1993",
month = "4",
day = "2",
doi = "10.1016/0304-3940(93)90483-2",
language = "English (US)",
volume = "152",
pages = "61--64",
journal = "Neuroscience Letters",
issn = "0304-3940",
publisher = "Elsevier Ireland Ltd",
number = "1-2",

}

TY - JOUR

T1 - Actions of clozapine and haloperidol on the extracellular levels of excitatory amino acids in the prefrontal cortex and striatum of conscious rats

AU - Daly, Darron A.

AU - Moghaddam, Bita

PY - 1993/4/2

Y1 - 1993/4/2

N2 - The technique of intracerebral microdialysis was employed to assess the effect of acute clozapine and haloperidol on the extracellular levels of aspartate and glutamate in the striatum and medial prefrontal cortex of conscious rats. Subcutaneous injection of 25 mg/kg clozapine, but not the lower dose of 15 mg/kg, led to a significant increase in both aspartate and glutamate levels over time. The maximum effect was observed two hours after injection. Haloperidol (0.5 and 1 mg/kg s.c.) did not increase the extracellular levels of aspartate and glutamate over time. At all doses tested, both drugs were without a significant effect in the striatum. These data suggest that clozapine may have selective actions on the cortical excitatory amino acid systems.

AB - The technique of intracerebral microdialysis was employed to assess the effect of acute clozapine and haloperidol on the extracellular levels of aspartate and glutamate in the striatum and medial prefrontal cortex of conscious rats. Subcutaneous injection of 25 mg/kg clozapine, but not the lower dose of 15 mg/kg, led to a significant increase in both aspartate and glutamate levels over time. The maximum effect was observed two hours after injection. Haloperidol (0.5 and 1 mg/kg s.c.) did not increase the extracellular levels of aspartate and glutamate over time. At all doses tested, both drugs were without a significant effect in the striatum. These data suggest that clozapine may have selective actions on the cortical excitatory amino acid systems.

KW - Clozapine

KW - Glutamate

KW - Haloperidol

KW - Microdialysis

KW - Prefrontal cortex

KW - Schizophrenia

UR - http://www.scopus.com/inward/record.url?scp=0027298969&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0027298969&partnerID=8YFLogxK

U2 - 10.1016/0304-3940(93)90483-2

DO - 10.1016/0304-3940(93)90483-2

M3 - Article

C2 - 8100055

AN - SCOPUS:0027298969

VL - 152

SP - 61

EP - 64

JO - Neuroscience Letters

JF - Neuroscience Letters

SN - 0304-3940

IS - 1-2

ER -