Acromegaly and zollinger-euison syndrome secondary to an islet cell tumor: Characterization and quantification of plasma and tumor human growth hormone-releasing factor

Darrell M. Wilson, Gian Paolo Ceda, David G. Bostwick, Robert J. Webber, Jerome R. Minkoff, Allan Pont, Raymond L. Hintz, Klaus G. Bensch, Ron G. Rosenfeld, Andrew R. Hoffman

Research output: Contribution to journalArticle

27 Scopus citations

Abstract

A young woman with acromegaly and Zollinger-Ellison syndrome associated with a GH-releasing factor (GRF)-and gastrin-secreting metastatic islet cell carcinoma was studied by means of specific antisera which recognize various regions of the GRF molecule. Using specific immunohistochemical techniques, the tumor cells were shown to contain GRF, gastrin, and gastrin-releasing peptide, but not GH. During a 4-h period, plasma GRF levels averaged 5.6 ± 1.4 ng/ml (±SD), while GH levels averaged 148 ± 71 ng/ml. GH secretion was pulsatile and increased after TRH administration. GRF RIAs may be useful in establishing the diagnosis of acromegaly secondary to the ectopic secretion of GRF.

Original languageEnglish (US)
Pages (from-to)1002-1005
Number of pages4
JournalJournal of Clinical Endocrinology and Metabolism
Volume59
Issue number5
DOIs
StatePublished - Nov 1984

ASJC Scopus subject areas

  • Endocrinology, Diabetes and Metabolism
  • Biochemistry
  • Endocrinology
  • Clinical Biochemistry
  • Biochemistry, medical

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    Wilson, D. M., Ceda, G. P., Bostwick, D. G., Webber, R. J., Minkoff, J. R., Pont, A., Hintz, R. L., Bensch, K. G., Rosenfeld, R. G., & Hoffman, A. R. (1984). Acromegaly and zollinger-euison syndrome secondary to an islet cell tumor: Characterization and quantification of plasma and tumor human growth hormone-releasing factor. Journal of Clinical Endocrinology and Metabolism, 59(5), 1002-1005. https://doi.org/10.1210/jcem-59-5-1002