Absorption of apomorphine by various routes in parkinsonism

Stephen T. Gancher, John G. Nutt, William R. Woodward

Research output: Contribution to journalArticlepeer-review

64 Scopus citations

Abstract

We wanted to determine the absorption and clinical effect of sublingual (SL) and transdermal apomorphine in parkinsonism. Patients received single SL apomorphine doses (N = 7) and the absorption was compared with parenteral (N = 5) and oral (N = 4) doses. One patient received a transdermal dose of apomorphine. The relative bioavalability of SL apomorphine ranged from 10 to 22% of a parenteral apomorphine dose. Oral apomorphine was less than 4% bioavailable, and the transdermal dose did not produce detectable plasma levels. Three patients with motor fluctuations responded to SL apomorphine, with a latency to effect of 20‐40 min and a duration of effect of 15‐100 min. One patient used SL apomorphine as an adjunct with levodopa, and during 1 month reported a large decrease in “off” periods. We conclude that apomorphine is effectively absorbed by the sublingual route.

Original languageEnglish (US)
Pages (from-to)212-216
Number of pages5
JournalMovement Disorders
Volume6
Issue number3
DOIs
StatePublished - 1991

Keywords

  • Apomorphine
  • Bioavailability
  • Parkinsonism
  • Sublingual

ASJC Scopus subject areas

  • Neurology
  • Clinical Neurology

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