Absorption of apomorphine by various routes in parkinsonism

Stephen T. Gancher, John G. Nutt, William R. Woodward

Research output: Contribution to journalArticle

62 Scopus citations

Abstract

We wanted to determine the absorption and clinical effect of sublingual (SL) and transdermal apomorphine in parkinsonism. Patients received single SL apomorphine doses (N = 7) and the absorption was compared with parenteral (N = 5) and oral (N = 4) doses. One patient received a transdermal dose of apomorphine. The relative bioavalability of SL apomorphine ranged from 10 to 22% of a parenteral apomorphine dose. Oral apomorphine was less than 4% bioavailable, and the transdermal dose did not produce detectable plasma levels. Three patients with motor fluctuations responded to SL apomorphine, with a latency to effect of 20‐40 min and a duration of effect of 15‐100 min. One patient used SL apomorphine as an adjunct with levodopa, and during 1 month reported a large decrease in “off” periods. We conclude that apomorphine is effectively absorbed by the sublingual route.

Original languageEnglish (US)
Pages (from-to)212-216
Number of pages5
JournalMovement Disorders
Volume6
Issue number3
DOIs
StatePublished - 1991

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Keywords

  • Apomorphine
  • Bioavailability
  • Parkinsonism
  • Sublingual

ASJC Scopus subject areas

  • Neurology
  • Clinical Neurology

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