Absence of type I estrogen receptors in choroidal melanoma: Analysis of Collaborative Ocular Melanoma Study (COMS) eyes

Richard J. Grostern, Ilona Slusker Shternfeld, Sarah S. Bacus, Kennedy Gilchrist, Michele L. Zimbric, Daniel M. Albert

Research output: Contribution to journalArticle

10 Scopus citations

Abstract

• PURPOSE: To evaluate choroidal melanomas in enucleated eyes for the presence of type I estrogen receptors. • METHODS: Fourteen consecutive eyes with large choroidal melanomas (defined as >16-mm basal diameter and >8 mm thickness) from 14 patients (eight women and six men with a mean age of 57 years; range, 25-74 years) enucleated in accordance with the Collaborative Ocular Melanoma Study (COMS) protocol were investigated. Immunohistochemical techniques were employed to label the choroidal melanomas for the presence of type I estrogen receptors. Each specimen was then evaluated in a masked fashion by an experienced ophthalmic pathologist for positive nuclear staining. •RESULTS: No tumors showed immunohistochemical evidence of a type I estrogen receptor. • CONCLUSION: Type I estrogen receptors are not present in choroidal melanoma. Estrogens are not likely to influence choroidal melanoma growth through traditional receptors.

Original languageEnglish (US)
Pages (from-to)788-791
Number of pages4
JournalAmerican journal of ophthalmology
Volume131
Issue number6
DOIs
StatePublished - Jun 21 2001

ASJC Scopus subject areas

  • Ophthalmology

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