Absence of type I estrogen receptors in choroidal melanoma: Analysis of Collaborative Ocular Melanoma Study (COMS) eyes

Richard J. Grostern, Ilona Slusker Shternfeld, Sarah S. Bacus, Kennedy Gilchrist, Michele L. Zimbric, Daniel Albert

Research output: Contribution to journalArticle

10 Citations (Scopus)

Abstract

• PURPOSE: To evaluate choroidal melanomas in enucleated eyes for the presence of type I estrogen receptors. • METHODS: Fourteen consecutive eyes with large choroidal melanomas (defined as >16-mm basal diameter and >8 mm thickness) from 14 patients (eight women and six men with a mean age of 57 years; range, 25-74 years) enucleated in accordance with the Collaborative Ocular Melanoma Study (COMS) protocol were investigated. Immunohistochemical techniques were employed to label the choroidal melanomas for the presence of type I estrogen receptors. Each specimen was then evaluated in a masked fashion by an experienced ophthalmic pathologist for positive nuclear staining. •RESULTS: No tumors showed immunohistochemical evidence of a type I estrogen receptor. • CONCLUSION: Type I estrogen receptors are not present in choroidal melanoma. Estrogens are not likely to influence choroidal melanoma growth through traditional receptors.

Original languageEnglish (US)
Pages (from-to)788-791
Number of pages4
JournalAmerican journal of ophthalmology
Volume131
Issue number6
DOIs
StatePublished - Jun 21 2001
Externally publishedYes

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Estrogen Receptors
Melanoma
Estrogens
Staining and Labeling
Growth
Neoplasms

ASJC Scopus subject areas

  • Ophthalmology

Cite this

Absence of type I estrogen receptors in choroidal melanoma : Analysis of Collaborative Ocular Melanoma Study (COMS) eyes. / Grostern, Richard J.; Shternfeld, Ilona Slusker; Bacus, Sarah S.; Gilchrist, Kennedy; Zimbric, Michele L.; Albert, Daniel.

In: American journal of ophthalmology, Vol. 131, No. 6, 21.06.2001, p. 788-791.

Research output: Contribution to journalArticle

Grostern, Richard J. ; Shternfeld, Ilona Slusker ; Bacus, Sarah S. ; Gilchrist, Kennedy ; Zimbric, Michele L. ; Albert, Daniel. / Absence of type I estrogen receptors in choroidal melanoma : Analysis of Collaborative Ocular Melanoma Study (COMS) eyes. In: American journal of ophthalmology. 2001 ; Vol. 131, No. 6. pp. 788-791.
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