Absence of pubertal gonadotropin secretion in girls with McCune-Albright syndrome

C. M. Foster, J. L. Ross, T. Shawker, O. H. Pescovitz, Donald (Lynn) Loriaux, G. B. Cutler, F. Comite

Research output: Contribution to journalArticle

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Abstract

Precocious puberty in girls with McCune-Albright syndrome has been attributed in some cases to early activation of the hypothalamic-pituitary-gonadal axis and in other cases to sex steroid secretion by apparently autonomous ovarian cysts. We evaluated serum gonadotropins and sex steroids in 6 girls (aged 1-9 yr) with McCune-Albright syndrome. The children had Tanner stage II-IV pubertal development. In 5 patients, nocturnal gonadotropin concentrations and the gonadotropin response to LHRH were within the normal range for prepubertal children. Thus, the precocious puberty in these patients could not be explained by activation of the hypothalamic-pituitary-ovarian axis. One child had high amplitude nocturnal pulses of serum LH and a LH-predominant response to LHRH. She was the oldest of the 6 girls and had a bone age of 13.5 yr which is within the range in which hypothalamic-pituitary-ovarian activation normally occurs. The children all had ovarian enlargement and ovarian cysts determined by ultrasound. It appears that precocious puberty in McCune-Albright syndrome may result from ovarian estrogen secretion in the absence of normal pubertal activation of the hypothalamic-pituitary-ovarian axis.

Original languageEnglish (US)
Pages (from-to)1161-1165
Number of pages5
JournalJournal of Clinical Endocrinology and Metabolism
Volume58
Issue number6
StatePublished - 1984
Externally publishedYes

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Polyostotic Fibrous Dysplasia
Gonadotropins
Precocious Puberty
Chemical activation
Ovarian Cysts
Gonadotropin-Releasing Hormone
Steroids
Serum
Bone
Estrogens
Reference Values
Ultrasonics
Bone and Bones

ASJC Scopus subject areas

  • Biochemistry
  • Endocrinology, Diabetes and Metabolism

Cite this

Foster, C. M., Ross, J. L., Shawker, T., Pescovitz, O. H., Loriaux, D. L., Cutler, G. B., & Comite, F. (1984). Absence of pubertal gonadotropin secretion in girls with McCune-Albright syndrome. Journal of Clinical Endocrinology and Metabolism, 58(6), 1161-1165.

Absence of pubertal gonadotropin secretion in girls with McCune-Albright syndrome. / Foster, C. M.; Ross, J. L.; Shawker, T.; Pescovitz, O. H.; Loriaux, Donald (Lynn); Cutler, G. B.; Comite, F.

In: Journal of Clinical Endocrinology and Metabolism, Vol. 58, No. 6, 1984, p. 1161-1165.

Research output: Contribution to journalArticle

Foster, CM, Ross, JL, Shawker, T, Pescovitz, OH, Loriaux, DL, Cutler, GB & Comite, F 1984, 'Absence of pubertal gonadotropin secretion in girls with McCune-Albright syndrome', Journal of Clinical Endocrinology and Metabolism, vol. 58, no. 6, pp. 1161-1165.
Foster, C. M. ; Ross, J. L. ; Shawker, T. ; Pescovitz, O. H. ; Loriaux, Donald (Lynn) ; Cutler, G. B. ; Comite, F. / Absence of pubertal gonadotropin secretion in girls with McCune-Albright syndrome. In: Journal of Clinical Endocrinology and Metabolism. 1984 ; Vol. 58, No. 6. pp. 1161-1165.
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