Absence of Epstein-Barr virus in lymphomatoid papulosis: An immunohistochemical and in situ hybridization study

Omar P. Sangüeza, Jenny Galloway, Phyllis A. Eagan, Rita M. Braziel, Margaret L. Gulley

Research output: Contribution to journalArticle

20 Scopus citations

Abstract

Background and Designs: Lymphomatoid papulosis (LyP) and cutaneous Hodgkin's disease share many clinical, histopathologic, and immunohistochemical features. Epstein-Barr virus (EBV) has been implicated in the pathogenesis of several lymphoid malignancies, including Hodgkin's disease. Given the similarities between LyP and Hodgkin's disease, we asked if EBV could be detected in lesions of LyP. We examined 31 specimens of LyP that were obtained from 24 patients for evidence of EBV by in situ hybridization to EBER1 transcripts and for immunohistochemistry of viral latent membrane protein 1 (LMP1). Results: In no instance was there any evidence of EBV gene products by either in situ hybridization or immunohistochemistry. Conclusions: The absence of EBV in LyP suggests that this virus is not operative in the pathogenesis of LyP. Furthermore, it suggests that LyP and Hodgkin's disease may not share the same molecular mechanisms despite their phenotypic similarities.

Original languageEnglish (US)
Pages (from-to)279-282
Number of pages4
JournalArchives of Dermatology
Volume132
Issue number3
DOIs
StatePublished - Mar 1 1996

ASJC Scopus subject areas

  • Dermatology

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