Abnormalities of circulating T-cell subpopulations in patients with cutaneous T-cell lymphoma

Cutaneous lymphocyte-associated antigen expression on T cells correlates with extent of disease

Michael J. Borowitz, Alison Weidner, Elise A. Olsen, Louis Picker

Research output: Contribution to journalArticle

55 Citations (Scopus)

Abstract

The recent characterization of the cutaneous lymphocyte-issociated antigen (CLA) as a skin-selective homing receptor lor skin-associated memory T cells has suggested a possible mechanism for the tropism demonstrated by the neoplastic T cells in cutaneous T-cell lymphoma (CTCL). In this study, we used five parameter flow cytometry to evaluate expression of CLA and the peripheral lymph node homing receptor L-selectin on circulating T cells in a series of patients with CTCL. Because CTCL cells were previously shown to be CD7-, we looked at expression of these receptors on the CD7- T-cell subset as well as on total T cells. Our results indicate that CTCL patients have increased levels of both CLA+ and CD7- cells in their peripheral blood and that these abnormalities are not seen in patients with other cutaneous disorders. The levels of the CLA-bearing subset correlated with extent of cutaneous but not lymph node disease. By contrast, the CD7- L-Selectin+ subset correlated with peripheral lymph node Involvement by CTCL. Only the CD7- L-selectin- subset correlated with the number of morphologically abnormal lymphocytes in the peripheral blood. The results support the hypothesis that expression of tissue-selective homing receptors contributes to the unique pattern of tissue involvement seen in patients with CTCL.

Original languageEnglish (US)
Pages (from-to)859-863
Number of pages5
JournalLeukemia
Volume7
Issue number6
StatePublished - Jun 1993
Externally publishedYes

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Cutaneous T-Cell Lymphoma
Lymphocytes
T-Lymphocytes
Antigens
Skin
L-Selectin
CD7 Antigens
Lymphocyte Homing Receptors
Lymph Nodes
Tropism
T-Lymphocyte Subsets
Flow Cytometry

ASJC Scopus subject areas

  • Cancer Research
  • Hematology

Cite this

Abnormalities of circulating T-cell subpopulations in patients with cutaneous T-cell lymphoma : Cutaneous lymphocyte-associated antigen expression on T cells correlates with extent of disease. / Borowitz, Michael J.; Weidner, Alison; Olsen, Elise A.; Picker, Louis.

In: Leukemia, Vol. 7, No. 6, 06.1993, p. 859-863.

Research output: Contribution to journalArticle

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abstract = "The recent characterization of the cutaneous lymphocyte-issociated antigen (CLA) as a skin-selective homing receptor lor skin-associated memory T cells has suggested a possible mechanism for the tropism demonstrated by the neoplastic T cells in cutaneous T-cell lymphoma (CTCL). In this study, we used five parameter flow cytometry to evaluate expression of CLA and the peripheral lymph node homing receptor L-selectin on circulating T cells in a series of patients with CTCL. Because CTCL cells were previously shown to be CD7-, we looked at expression of these receptors on the CD7- T-cell subset as well as on total T cells. Our results indicate that CTCL patients have increased levels of both CLA+ and CD7- cells in their peripheral blood and that these abnormalities are not seen in patients with other cutaneous disorders. The levels of the CLA-bearing subset correlated with extent of cutaneous but not lymph node disease. By contrast, the CD7- L-Selectin+ subset correlated with peripheral lymph node Involvement by CTCL. Only the CD7- L-selectin- subset correlated with the number of morphologically abnormal lymphocytes in the peripheral blood. The results support the hypothesis that expression of tissue-selective homing receptors contributes to the unique pattern of tissue involvement seen in patients with CTCL.",
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