Abnormal development of peripheral lymphoid organs in mice deficient in lymphotoxin

Pietro De Togni, Joseph Goellner, Nancy H. Ruddle, Philip Streeter, Andrea Fick, Sanjeev Mariathasan, Stacy C. Smith, Rebecca Carlson, Laurie P. Shornick, Jena Strauss-Schoenberger, John H. Russell, Robert Karr, David D. Chaplin

Research output: Contribution to journalArticle

814 Citations (Scopus)

Abstract

Mice rendered deficient in lymphotoxin (LT) by gene targeting in embryonic stem cells have no morphologically detectable lymph nodes or Peyer's patches, although development of the thymus appears normal. Within the white pulp of the spleen, there is failure of normal segregation of B and T cells. Spleen and peripheral blood contain CD4+CD8- and CD4-CD8+ T cells in a normal ratio, and both T cell subsets have an apparently normal lytic function. Lymphocytes positive for immunoglobulin M are present in increased numbers in both the spleen and peripheral blood. These data suggest an essential role for LT in the normal development of peripheral lymphoid organs.

Original languageEnglish (US)
Pages (from-to)703-707
Number of pages5
JournalScience
Volume264
Issue number5159
StatePublished - Apr 29 1994
Externally publishedYes

Fingerprint

Lymphotoxin-alpha
Spleen
T-Lymphocytes
Peyer's Patches
Gene Targeting
T-Lymphocyte Subsets
Embryonic Stem Cells
Thymus Gland
Immunoglobulin M
B-Lymphocytes
Lymph Nodes
Lymphocytes

ASJC Scopus subject areas

  • General

Cite this

De Togni, P., Goellner, J., Ruddle, N. H., Streeter, P., Fick, A., Mariathasan, S., ... Chaplin, D. D. (1994). Abnormal development of peripheral lymphoid organs in mice deficient in lymphotoxin. Science, 264(5159), 703-707.

Abnormal development of peripheral lymphoid organs in mice deficient in lymphotoxin. / De Togni, Pietro; Goellner, Joseph; Ruddle, Nancy H.; Streeter, Philip; Fick, Andrea; Mariathasan, Sanjeev; Smith, Stacy C.; Carlson, Rebecca; Shornick, Laurie P.; Strauss-Schoenberger, Jena; Russell, John H.; Karr, Robert; Chaplin, David D.

In: Science, Vol. 264, No. 5159, 29.04.1994, p. 703-707.

Research output: Contribution to journalArticle

De Togni, P, Goellner, J, Ruddle, NH, Streeter, P, Fick, A, Mariathasan, S, Smith, SC, Carlson, R, Shornick, LP, Strauss-Schoenberger, J, Russell, JH, Karr, R & Chaplin, DD 1994, 'Abnormal development of peripheral lymphoid organs in mice deficient in lymphotoxin', Science, vol. 264, no. 5159, pp. 703-707.
De Togni P, Goellner J, Ruddle NH, Streeter P, Fick A, Mariathasan S et al. Abnormal development of peripheral lymphoid organs in mice deficient in lymphotoxin. Science. 1994 Apr 29;264(5159):703-707.
De Togni, Pietro ; Goellner, Joseph ; Ruddle, Nancy H. ; Streeter, Philip ; Fick, Andrea ; Mariathasan, Sanjeev ; Smith, Stacy C. ; Carlson, Rebecca ; Shornick, Laurie P. ; Strauss-Schoenberger, Jena ; Russell, John H. ; Karr, Robert ; Chaplin, David D. / Abnormal development of peripheral lymphoid organs in mice deficient in lymphotoxin. In: Science. 1994 ; Vol. 264, No. 5159. pp. 703-707.
@article{1d92eff073f34a99816bfae860b5f716,
title = "Abnormal development of peripheral lymphoid organs in mice deficient in lymphotoxin",
abstract = "Mice rendered deficient in lymphotoxin (LT) by gene targeting in embryonic stem cells have no morphologically detectable lymph nodes or Peyer's patches, although development of the thymus appears normal. Within the white pulp of the spleen, there is failure of normal segregation of B and T cells. Spleen and peripheral blood contain CD4+CD8- and CD4-CD8+ T cells in a normal ratio, and both T cell subsets have an apparently normal lytic function. Lymphocytes positive for immunoglobulin M are present in increased numbers in both the spleen and peripheral blood. These data suggest an essential role for LT in the normal development of peripheral lymphoid organs.",
author = "{De Togni}, Pietro and Joseph Goellner and Ruddle, {Nancy H.} and Philip Streeter and Andrea Fick and Sanjeev Mariathasan and Smith, {Stacy C.} and Rebecca Carlson and Shornick, {Laurie P.} and Jena Strauss-Schoenberger and Russell, {John H.} and Robert Karr and Chaplin, {David D.}",
year = "1994",
month = "4",
day = "29",
language = "English (US)",
volume = "264",
pages = "703--707",
journal = "Science",
issn = "0036-8075",
publisher = "American Association for the Advancement of Science",
number = "5159",

}

TY - JOUR

T1 - Abnormal development of peripheral lymphoid organs in mice deficient in lymphotoxin

AU - De Togni, Pietro

AU - Goellner, Joseph

AU - Ruddle, Nancy H.

AU - Streeter, Philip

AU - Fick, Andrea

AU - Mariathasan, Sanjeev

AU - Smith, Stacy C.

AU - Carlson, Rebecca

AU - Shornick, Laurie P.

AU - Strauss-Schoenberger, Jena

AU - Russell, John H.

AU - Karr, Robert

AU - Chaplin, David D.

PY - 1994/4/29

Y1 - 1994/4/29

N2 - Mice rendered deficient in lymphotoxin (LT) by gene targeting in embryonic stem cells have no morphologically detectable lymph nodes or Peyer's patches, although development of the thymus appears normal. Within the white pulp of the spleen, there is failure of normal segregation of B and T cells. Spleen and peripheral blood contain CD4+CD8- and CD4-CD8+ T cells in a normal ratio, and both T cell subsets have an apparently normal lytic function. Lymphocytes positive for immunoglobulin M are present in increased numbers in both the spleen and peripheral blood. These data suggest an essential role for LT in the normal development of peripheral lymphoid organs.

AB - Mice rendered deficient in lymphotoxin (LT) by gene targeting in embryonic stem cells have no morphologically detectable lymph nodes or Peyer's patches, although development of the thymus appears normal. Within the white pulp of the spleen, there is failure of normal segregation of B and T cells. Spleen and peripheral blood contain CD4+CD8- and CD4-CD8+ T cells in a normal ratio, and both T cell subsets have an apparently normal lytic function. Lymphocytes positive for immunoglobulin M are present in increased numbers in both the spleen and peripheral blood. These data suggest an essential role for LT in the normal development of peripheral lymphoid organs.

UR - http://www.scopus.com/inward/record.url?scp=0028277665&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0028277665&partnerID=8YFLogxK

M3 - Article

C2 - 8171322

AN - SCOPUS:0028277665

VL - 264

SP - 703

EP - 707

JO - Science

JF - Science

SN - 0036-8075

IS - 5159

ER -