@article{fba95c2a7153444381fbb2cd9c1fa5c1,
title = "AAV-PHP.B Administration Results in a Differential Pattern of CNS Biodistribution in Non-human Primates Compared with Mice",
abstract = "Liguore and colleagues characterize biodistribution of AAV-PHP.B in the rodent and rhesus macaque CNS following intra-CSF and intravascular delivery modalities. Although equal transduction efficiency was seen in mice regardless of delivery route, intra-cisterna magna infusion led to superior transduction efficiency compared with intra-carotid artery infusion in the rhesus macaque CNS.",
keywords = "AAV-PHP.B, AAV9, CNS, adeno-associated virus, brain, gene therapy, gene transfer, mouse, rhesus macaque, viral transduction",
author = "Liguore, {William A.} and Domire, {Jacqueline S.} and Dana Button and Yun Wang and Dufour, {Brett D.} and Sathya Srinivasan and McBride, {Jodi L.}",
note = "Funding Information: J.L.M. has previously been a paid consultant for Spark Therapeutics and is currently a paid consultant for Takeda Pharmaceutical Company. J.L.M. is also currently receiving financial compensation for consulting with investigators at Rush University Medical Center and The University at Albany-SUNY regarding an award funded via the Michael J. Fox Foundation for Parkinson{\textquoteright}s Research. All other authors declare no competing interests. Funding Information: We thank Drs. Ben Deverman and Viviana Gradinaru for their generous use of the pAAV.PHP.B-EGFP plasmids. We thank Christoph Kahl and Michelle Gomes in the OHSU MVSC Core for production of the recombinant AAV-PHP.B viral vectors. We thank the ONPRC Small Laboratory Animals Unit and the Division of Comparative Medicine for the outstanding care of our mice and rhesus macaques, with special thanks to Darla Jacobs, Lauren Drew Martin, and Theodore Hobbs. We thank the ONPRC Pathology Unit for their expertise and assistance with necropsy and pathology. Finally, we thank Dr. Alison Weiss for her thoughtful edits on this manuscript. This research was supported by NIH Award NS099136 (J.L.M.) and The Bev Hartig Huntington's Disease Foundation (J.L.M.). This work was also supported by the Integrated Pathology Core at the ONPRC, which is supported by NIH Core Grant P51OD011092 and NIH Instrumentation Grant 1S10OD025002-01. Publisher Copyright: {\textcopyright} 2019 The American Society of Gene and Cell Therapy",
year = "2019",
month = nov,
day = "6",
doi = "10.1016/j.ymthe.2019.07.017",
language = "English (US)",
volume = "27",
pages = "2018--2037",
journal = "Molecular Therapy",
issn = "1525-0016",
publisher = "Nature Publishing Group",
number = "11",
}