A tumor suppressor role for PP2A-B56α through negative regulation of c-Myc and other key oncoproteins

Hugh K. Arnold, Rosalie C. Sears

Research output: Contribution to journalReview article

74 Scopus citations

Abstract

Loss or inhibition of the serine/threonine protein phosphatase 2A (PP2A) has revealed a critical tumor suppressor function for PP2A. However, PP2A has also been shown to have important roles in cell cycle progression and survival. Therefore, PP2A is not a typical tumor suppressor. This is most likely due to the fact that PP2A represents a large number of different holoenzymes. Further understanding of PP2A function(s), and especially its tumor suppressor activity, will depend largely on our ability to determine specific targets for these different PP2A holoenzymes and to gain an understanding of how these targets confer tumor suppressor activity or contribute to cell cycle progression and cell survival. Recent work has identified c-Myc as a target of the PP2A holoenzyme, PP2A-B56α. This holoenzyme also negatively regulates β-catenin expression and modulates the anti-apoptotic activity of Bcl2, thus characterizing PP2A-B56α as a tumor suppressor PP2A holoenzyme. This review will focus on the role of PP2A-B56α in regulating c-Myc and will place this tumor suppressor activity of PP2A within the context of its other tumor suppressor functions. Finally, the mechanism(s) through which PP2A-B56α tumor suppressor activity may be lost in cancer will be discussed.

Original languageEnglish (US)
Pages (from-to)147-158
Number of pages12
JournalCancer and Metastasis Reviews
Volume27
Issue number2
DOIs
StatePublished - Jun 1 2008

Keywords

  • B56α
  • PP2A
  • Tumor suppressor
  • c-Myc

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

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