A Trial of Amitriptyline and Fluphenazine in the Treatment of Painful Diabetic Neuropathy

Carl M. Mendel, Robert F. Klein, David A. Chappell, Willard H. Dere, Barry J. Gertz, John H. Karam, Thomas N. Lavin, Carl Grunfeld

Research output: Contribution to journalArticle

39 Scopus citations

Abstract

We conducted a double-blind, placebo-controlled, crossover study of the effectiveness of amitriptyline and fluphenazine in alleviating the pain of diabetic peripheral neuropathy in six diabetic patients. Pain was evaluated by the patients with a graphic rating scale. A placebo response was found, but no additional effect of amitriptyline and fluphenazine was seen. Although the statistical power of this study was low, these data, when combined with a reevaluation of previous trials of amitriptyline and fluphenazine in the treatment of painful diabetic neuropathy, indicate that there is no justification for the use of these agents in the treatment of painful neuropathy outside of large, controlled clinical trials. Depression as a possible cause of this condition should not go unnoted or untreated.

Original languageEnglish (US)
Pages (from-to)637-639
Number of pages3
JournalJAMA: The Journal of the American Medical Association
Volume255
Issue number5
DOIs
StatePublished - Feb 7 1986

ASJC Scopus subject areas

  • Medicine(all)

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