A tissue culture model of methyl ethyl ketone's potentiation of n-hexane neurotoxicity

B. Veronesi, A. W. Lington, Peter Spencer

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

Recent clinical and experimental animal studies indicate that methyl ethyl ketone (MEK), a widely used industrial solvent, can potentiate hexacarbon neurotoxicity. Organotypic tissue cultures, consisting of fetal mouse spinal cord, dorsal root ganglia, and muscle were used to reproduce this interaction. Cultures exposed to mixtures of MEK and neurotoxic doses of n-hexane developed giant axonal swellings more rapidly than those treated with equivalent doses of n-hexane alone. Cultures exposed to 'no-response' doses of n-hexane in combination with MEK also developed axonal swellings. In addition, occasional cultures exposed to high levels of MEK alone and in certain combinations with n-hexane developed intra-axonal inclusions which were identified by electron microscopy to be foci of axoplasmic debris.

Original languageEnglish (US)
Pages (from-to)43-52
Number of pages10
JournalNeuroToxicology
Volume5
Issue number2
StatePublished - 1984
Externally publishedYes

Fingerprint

Tissue culture
Swelling
Spinal Ganglia
Debris
Electron microscopy
Muscle
Spinal Cord
Electron Microscopy
Animals
Muscles
methylethyl ketone
n-hexane

ASJC Scopus subject areas

  • Neuroscience(all)
  • Cellular and Molecular Neuroscience
  • Toxicology

Cite this

A tissue culture model of methyl ethyl ketone's potentiation of n-hexane neurotoxicity. / Veronesi, B.; Lington, A. W.; Spencer, Peter.

In: NeuroToxicology, Vol. 5, No. 2, 1984, p. 43-52.

Research output: Contribution to journalArticle

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