A telemetric study of physiologic changes in mice with induced autoimmune encephalomyelitis

Abigail C. Buenafe, Heather Zwickey, Nicole Moes, Barry Oken, Richard E. Jones

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

Dysfunction of the autonomic nervous system may be an important component of disease progression in multiple sclerosis (MS), a paralytic inflammatory autoimmune disease of the central nervous system. Using the experimental autoimmune encephalomyelitis mouse model of MS, the authors carried out a pilot study to investigate whether telemetric monitoring might be a feasible approach for detecting disturbances in the autonomic control of heart rate and blood pressure after disease induction. Telemetric monitoring devices that were implanted in mice provided useful information regarding the physiologic changes that accompanied disease induction and progression. Changes were observed in heart rate, blood pressure, heart rate variability and diurnal rhythm immediately before and after disease onset. The device implantation procedure did not seem to alter the course of disease. Further investigation may establish these methods as a system for studying the relationships between MS progression and autonomic regulation of physiological status.

Original languageEnglish (US)
Pages (from-to)361-368
Number of pages8
JournalLab Animal
Volume37
Issue number8
DOIs
StatePublished - Aug 2008

Fingerprint

Encephalomyelitis
sclerosis
encephalitis
Multiple Sclerosis
heart rate
Heart Rate
disease course
blood pressure
Disease Progression
mice
Autoimmune Diseases of the Nervous System
Blood Pressure
autonomic nervous system
Equipment and Supplies
Autoimmune Experimental Encephalomyelitis
monitoring
autoimmune diseases
Autonomic Nervous System
Blood pressure
Neurology

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • Medicine (miscellaneous)
  • veterinary(all)

Cite this

A telemetric study of physiologic changes in mice with induced autoimmune encephalomyelitis. / Buenafe, Abigail C.; Zwickey, Heather; Moes, Nicole; Oken, Barry; Jones, Richard E.

In: Lab Animal, Vol. 37, No. 8, 08.2008, p. 361-368.

Research output: Contribution to journalArticle

Buenafe, Abigail C. ; Zwickey, Heather ; Moes, Nicole ; Oken, Barry ; Jones, Richard E. / A telemetric study of physiologic changes in mice with induced autoimmune encephalomyelitis. In: Lab Animal. 2008 ; Vol. 37, No. 8. pp. 361-368.
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