A system biology approach to identify regulatory pathways underlying the neuroendocrine control of female puberty in rats and nonhuman primates

Alejandro Lomniczi, Hollis Wright, Juan Manuel Castellano, Mustafa (Kemal) Sonmez, Sergio Ojeda

Research output: Contribution to journalArticle

27 Citations (Scopus)

Abstract

This article is part of a Special Issue "Puberty and Adolescence".Puberty is a major developmental milestone controlled by the interaction of genetic factors and environmental cues of mostly metabolic and circadian nature. An increased pulsatile release of the decapeptide gonadotropin releasing hormone (GnRH) from hypothalamic neurosecretory neurons is required for both the initiation and progression of the pubertal process. This increase is brought about by coordinated changes that occur in neuronal and glial networks associated with GnRH neurons. These changes ultimately result in increased neuronal and glial stimulatory inputs to the GnRH neuronal network and a reduction of transsynaptic inhibitory influences. While some of the major players controlling pubertal GnRH secretion have been identified using gene-centric approaches, much less is known about the system-wide control of the overall process. Because the pubertal activation of GnRH release involves a diversity of cellular phenotypes, and a myriad of intracellular and cell-to-cell signaling molecules, it appears that the overall process is controlled by a highly coordinated and interactive regulatory system involving hundreds, if not thousands, of gene products. In this article we will discuss emerging evidence suggesting that these genes are arranged as functionally connected networks organized, both internally and across sub-networks, in a hierarchical fashion. According to this concept, the core of these networks is composed of transcriptional regulators that, by directing expression of downstream subordinate genes, provide both stability and coordination to the cellular networks involved in initiating the pubertal process. The integrative response of these gene networks to external inputs is postulated to be coordinated by epigenetic mechanisms.

Original languageEnglish (US)
Pages (from-to)175-186
Number of pages12
JournalHormones and Behavior
Volume64
Issue number2
DOIs
StatePublished - Jul 2013

Fingerprint

Systems Biology
Puberty
Gonadotropin-Releasing Hormone
Primates
Neuroglia
Genes
Neurons
Gene Regulatory Networks
Epigenomics
Cues
Phenotype

Keywords

  • Female puberty
  • Gene networks
  • Glial-neuronal communication
  • Hypothalamus
  • Neuroendocrine control
  • Neurotransmission
  • Systems biology
  • Transcriptional regulation

ASJC Scopus subject areas

  • Endocrinology
  • Behavioral Neuroscience
  • Endocrine and Autonomic Systems

Cite this

A system biology approach to identify regulatory pathways underlying the neuroendocrine control of female puberty in rats and nonhuman primates. / Lomniczi, Alejandro; Wright, Hollis; Castellano, Juan Manuel; Sonmez, Mustafa (Kemal); Ojeda, Sergio.

In: Hormones and Behavior, Vol. 64, No. 2, 07.2013, p. 175-186.

Research output: Contribution to journalArticle

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