A Study of High-Grade Serous Ovarian Cancer Origins Implicates the SOX18 Transcription Factor in Tumor Development

Kate Lawrenson, Marcos A.S. Fonseca, Annie Y. Liu, Felipe Segato Dezem, Janet M. Lee, Xianzhi Lin, Rosario I. Corona, Forough Abbasi, Kevin C. Vavra, Huy Q. Dinh, Navjot Kaur Gill, Ji Heui Seo, Simon Coetzee, Yvonne G. Lin, Tanja Pejovic, Paulette Mhawech-Fauceglia, Amy C. Rowat, Ronny Drapkin, Beth Y. Karlan, Dennis J. HazelettMatthew L. Freedman, Simon A. Gayther, Houtan Noushmehr

Research output: Contribution to journalArticlepeer-review

14 Scopus citations

Abstract

Lawrenson et al. profile gene expression and active chromatin in ∼200 ovarian and fallopian epithelial isolates and implement machine learning to demonstrate that most high-grade serous ovarian cancers (HGSOCs) derive from fallopian tube epithelial cells, but a subset may originate from ovarian epithelia. SOX18 induces mesenchymal features to drive early neoplasia in fallopian tube precursors.

Original languageEnglish (US)
Pages (from-to)3726-3735.e4
JournalCell Reports
Volume29
Issue number11
DOIs
StatePublished - Dec 10 2019

Keywords

  • RNA-seq
  • SOX18
  • dual origins
  • fallopian tube secretory epithelial cell
  • high-grade serous ovarian cancer
  • machine learning
  • one-class logistic regression models
  • ovarian surface epithelial cell
  • single-cell RNA-seq
  • super enhancers
  • transcription factors

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

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