A safety assessment of branched chain saturated alcohols when used as fragrance ingredients

D. Belsito, D. Bickers, M. Bruze, P. Calow, H. Greim, Jon Hanifin, A. E. Rogers, J. H. Saurat, I. G. Sipes, H. Tagami

Research output: Contribution to journalArticle

33 Citations (Scopus)

Abstract

The Branched Chain Saturated Alcohol (BCSA) group of fragrance ingredients was evaluated for safety. In humans, no evidence of skin irritation was found at concentrations of 2-10%. Undiluted, 11 materials evaluated caused moderate to severe eye irritation. As current end product use levels are between 0.001% and 1.7%, eye irritation is not a concern. The materials have no or low sensitizing potential. For individuals who are already sensitized, an elicitation reaction is possible. Due to lack of UVA/UVB light-absorbing structures, and review of phototoxic/photoallergy data, the BCSA are not expected to elicit phototoxicity or photoallergy. The 15 materials tested have a low order of acute toxicity. Following repeated application, seven BCSA tested were of low systemic toxicity. Studies performed on eight BCSA and three metabolites show no in vivo or in vitro genotoxicity. A valid carcinogenicity study showed that 2-ethyl-1-hexanol is a weak inducer of liver tumors in female mice, however, the relevance of this effect and mode of action to humans is still a matter of debate. The Panel is of the opinion that there are no safety concerns regarding BCSA under the present levels of use and exposure.

Original languageEnglish (US)
JournalFood and Chemical Toxicology
Volume48
Issue numberSUPPL. 4
DOIs
StatePublished - Jul 2010

Fingerprint

Fragrances
safety assessment
ingredients
alcohols
odors
Alcohols
Safety
Photoallergic Dermatitis
eye irritation
Toxicity
phototoxicity
Phototoxic Dermatitis
skin irritation
carcinogenicity
liver neoplasms
genotoxicity
acute toxicity
Metabolites
Liver
ultraviolet radiation

Keywords

  • Branched chain saturated alcohols
  • Fragrance ingredients
  • Review
  • Safety

ASJC Scopus subject areas

  • Food Science
  • Toxicology

Cite this

A safety assessment of branched chain saturated alcohols when used as fragrance ingredients. / Belsito, D.; Bickers, D.; Bruze, M.; Calow, P.; Greim, H.; Hanifin, Jon; Rogers, A. E.; Saurat, J. H.; Sipes, I. G.; Tagami, H.

In: Food and Chemical Toxicology, Vol. 48, No. SUPPL. 4, 07.2010.

Research output: Contribution to journalArticle

Belsito, D, Bickers, D, Bruze, M, Calow, P, Greim, H, Hanifin, J, Rogers, AE, Saurat, JH, Sipes, IG & Tagami, H 2010, 'A safety assessment of branched chain saturated alcohols when used as fragrance ingredients', Food and Chemical Toxicology, vol. 48, no. SUPPL. 4. https://doi.org/10.1016/j.fct.2010.05.046
Belsito, D. ; Bickers, D. ; Bruze, M. ; Calow, P. ; Greim, H. ; Hanifin, Jon ; Rogers, A. E. ; Saurat, J. H. ; Sipes, I. G. ; Tagami, H. / A safety assessment of branched chain saturated alcohols when used as fragrance ingredients. In: Food and Chemical Toxicology. 2010 ; Vol. 48, No. SUPPL. 4.
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