A role for the helix-loop-helix protein Id2 in the control of oligodendrocyte development

Songli Wang, Andrei Sdrulla, Jane E. Johnson, Yoshifumi Yokota, Ben A. Barres

Research output: Contribution to journalArticle

193 Citations (Scopus)

Abstract

Compared to neurons, the intracellular mechanisms that control glial differentiation are still poorly understood. We show here that oligodendrocyte lineage cells express the helix-loop-helix proteins Mash1 and Id2. Although Mash1 has been found to regulate neuronal development, we found that in the absence of Mash1 oligodendrocyte differentiation occurs normally. In contrast, we found that overexpression of Id2 powerfully inhibits oligodendrocyte differentiation, that Id2 normally translocates out of the nucleus at the onset of differentiation, and that absence of Id2 induces premature oligodendrocyte differentiation in vitro. These findings demonstrate that Id2 is a component of the intracellular mechanism that times oligodendrocyte differentiation and point to the existence of an as yet unidentified MyoD-like bHLH protein necessary for oligodendrocyte differentiation.

Original languageEnglish (US)
Pages (from-to)603-614
Number of pages12
JournalNeuron
Volume29
Issue number3
DOIs
StatePublished - 2001
Externally publishedYes

Fingerprint

Oligodendroglia
Proteins
Basic Helix-Loop-Helix Transcription Factors
Neuroglia
Neurons

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

A role for the helix-loop-helix protein Id2 in the control of oligodendrocyte development. / Wang, Songli; Sdrulla, Andrei; Johnson, Jane E.; Yokota, Yoshifumi; Barres, Ben A.

In: Neuron, Vol. 29, No. 3, 2001, p. 603-614.

Research output: Contribution to journalArticle

Wang, Songli ; Sdrulla, Andrei ; Johnson, Jane E. ; Yokota, Yoshifumi ; Barres, Ben A. / A role for the helix-loop-helix protein Id2 in the control of oligodendrocyte development. In: Neuron. 2001 ; Vol. 29, No. 3. pp. 603-614.
@article{a97111d66802492bbdcf39a648ecfb37,
title = "A role for the helix-loop-helix protein Id2 in the control of oligodendrocyte development",
abstract = "Compared to neurons, the intracellular mechanisms that control glial differentiation are still poorly understood. We show here that oligodendrocyte lineage cells express the helix-loop-helix proteins Mash1 and Id2. Although Mash1 has been found to regulate neuronal development, we found that in the absence of Mash1 oligodendrocyte differentiation occurs normally. In contrast, we found that overexpression of Id2 powerfully inhibits oligodendrocyte differentiation, that Id2 normally translocates out of the nucleus at the onset of differentiation, and that absence of Id2 induces premature oligodendrocyte differentiation in vitro. These findings demonstrate that Id2 is a component of the intracellular mechanism that times oligodendrocyte differentiation and point to the existence of an as yet unidentified MyoD-like bHLH protein necessary for oligodendrocyte differentiation.",
author = "Songli Wang and Andrei Sdrulla and Johnson, {Jane E.} and Yoshifumi Yokota and Barres, {Ben A.}",
year = "2001",
doi = "10.1016/S0896-6273(01)00237-9",
language = "English (US)",
volume = "29",
pages = "603--614",
journal = "Neuron",
issn = "0896-6273",
publisher = "Cell Press",
number = "3",

}

TY - JOUR

T1 - A role for the helix-loop-helix protein Id2 in the control of oligodendrocyte development

AU - Wang, Songli

AU - Sdrulla, Andrei

AU - Johnson, Jane E.

AU - Yokota, Yoshifumi

AU - Barres, Ben A.

PY - 2001

Y1 - 2001

N2 - Compared to neurons, the intracellular mechanisms that control glial differentiation are still poorly understood. We show here that oligodendrocyte lineage cells express the helix-loop-helix proteins Mash1 and Id2. Although Mash1 has been found to regulate neuronal development, we found that in the absence of Mash1 oligodendrocyte differentiation occurs normally. In contrast, we found that overexpression of Id2 powerfully inhibits oligodendrocyte differentiation, that Id2 normally translocates out of the nucleus at the onset of differentiation, and that absence of Id2 induces premature oligodendrocyte differentiation in vitro. These findings demonstrate that Id2 is a component of the intracellular mechanism that times oligodendrocyte differentiation and point to the existence of an as yet unidentified MyoD-like bHLH protein necessary for oligodendrocyte differentiation.

AB - Compared to neurons, the intracellular mechanisms that control glial differentiation are still poorly understood. We show here that oligodendrocyte lineage cells express the helix-loop-helix proteins Mash1 and Id2. Although Mash1 has been found to regulate neuronal development, we found that in the absence of Mash1 oligodendrocyte differentiation occurs normally. In contrast, we found that overexpression of Id2 powerfully inhibits oligodendrocyte differentiation, that Id2 normally translocates out of the nucleus at the onset of differentiation, and that absence of Id2 induces premature oligodendrocyte differentiation in vitro. These findings demonstrate that Id2 is a component of the intracellular mechanism that times oligodendrocyte differentiation and point to the existence of an as yet unidentified MyoD-like bHLH protein necessary for oligodendrocyte differentiation.

UR - http://www.scopus.com/inward/record.url?scp=0035052390&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0035052390&partnerID=8YFLogxK

U2 - 10.1016/S0896-6273(01)00237-9

DO - 10.1016/S0896-6273(01)00237-9

M3 - Article

C2 - 11301021

AN - SCOPUS:0035052390

VL - 29

SP - 603

EP - 614

JO - Neuron

JF - Neuron

SN - 0896-6273

IS - 3

ER -