A review of transfusion practice before, during, and after hematopoietic progenitor cell transplantation

James L. Gajewski, Viviana V. Johnson, S. Gerald Sandler, Antoine Sayegh, Thomas R. Klumpp

    Research output: Contribution to journalReview article

    61 Scopus citations

    Abstract

    The increased use of hematopoietic progenitor cell (HPC) transplantation has implications and consequences for transfusion services: not only in hospitals where HPC transplantations are performed, but also in hospitals that do not perform HPC transplantations but manage patients before or after transplantation. Candidates for HPC transplantation have specific and specialized transfusion requirements before, during, and after transplantation that are necessary to avert the adverse consequences of alloimmunization to human leukocyte antigens, immunohematologic consequences of ABO-mismatched transplantations, or immunosuppression. Decisions concerning blood transfusions during any of these times may compromise the outcome of an otherwise successful transplantation. Years after an HPC transplantation, and even during clinical remission, recipients may continue to be immunosuppressed and may have critically important, special transfusion requirements. Without a thorough understanding of these special requirements, provision of compatible blood components may be delayed and often urgent transfusion needs prohibit appropriate consultation with the patient's transplantation specialist. To optimize the relevance of issues and communication between clinical hematologists, transplantation physicians, and transfusion medicine physicians, the data and opinions presented in this review are organized by sequence of patient presentation, namely, before, during, and after transplantation.

    Original languageEnglish (US)
    Pages (from-to)3036-3047
    Number of pages12
    JournalBlood
    Volume112
    Issue number8
    DOIs
    StatePublished - Oct 15 2008

    ASJC Scopus subject areas

    • Biochemistry
    • Immunology
    • Hematology
    • Cell Biology

    Fingerprint Dive into the research topics of 'A review of transfusion practice before, during, and after hematopoietic progenitor cell transplantation'. Together they form a unique fingerprint.

  • Cite this

    Gajewski, J. L., Johnson, V. V., Sandler, S. G., Sayegh, A., & Klumpp, T. R. (2008). A review of transfusion practice before, during, and after hematopoietic progenitor cell transplantation. Blood, 112(8), 3036-3047. https://doi.org/10.1182/blood-2007-10-118372