A Review of Adverse Reactions to Biologics Used in Allergy-Immunology Practice

Timothy G. Chow, John Oppenheimer, Shyam R. Joshi

Research output: Contribution to journalArticlepeer-review


Biologic agents have become an integral therapeutic option for practicing allergists-immunologists for the management of asthma, atopic dermatitis, chronic rhinosinusitis with nasal polyps, and various immunologic conditions. As these agents vary considerably from traditional small-molecule drugs, various adverse reactions have been noted. A different approach must be used to classify these reactions beyond the classic Gell-Coombs classification system as it does not capture many of the adverse events seen with biologic therapy. This article addresses the available literature on proposed classification systems and diagnostic modalities for adverse events associated with biologics and reviews each approved agent used frequently in allergy-immunology practice.

Original languageEnglish (US)
Pages (from-to)3075-3086
Number of pages12
JournalJournal of Allergy and Clinical Immunology: In Practice
Issue number12
StatePublished - Dec 2022


  • Adverse events
  • Allergic reactions
  • Biologics

ASJC Scopus subject areas

  • Immunology and Allergy


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