@article{c76e687f56b14eeda63ba2481374b2d3,
title = "A Review of Adverse Reactions to Biologics Used in Allergy-Immunology Practice",
abstract = "Biologic agents have become an integral therapeutic option for practicing allergists-immunologists for the management of asthma, atopic dermatitis, chronic rhinosinusitis with nasal polyps, and various immunologic conditions. As these agents vary considerably from traditional small-molecule drugs, various adverse reactions have been noted. A different approach must be used to classify these reactions beyond the classic Gell-Coombs classification system as it does not capture many of the adverse events seen with biologic therapy. This article addresses the available literature on proposed classification systems and diagnostic modalities for adverse events associated with biologics and reviews each approved agent used frequently in allergy-immunology practice.",
keywords = "Adverse events, Allergic reactions, Biologics",
author = "Chow, {Timothy G.} and John Oppenheimer and Joshi, {Shyam R.}",
note = "Funding Information: No funding was received for this work. Conflicts of interest: S. R. Joshi has participated on advisory boards for Biocryst, Sanofi, Noho Allergy, Takeda, and Leo Pharma, and declares that he is a consultant and owns stock in Nectar Allergy. J. Oppenheimer declares that he is on the data and safety monitoring board for AstraZeneca, Amgen, GlaxoSmithKline, Sanofi/Regeneron, and Abbvie. He is a consultant for GlaxoSmithKline, Aquestive, Aimmune, and Amgen; and is an executive editor for Annals of Allergy, Asthma, and Immunology, UpToDate reviewer, and section editor for Medscape. T. G. Chow declares that he received the Allergists{\textquoteright} Foundation Community Grant (ACAAI) and was ACAAI Fellow-in-Training representative to the Board of Regents 2019-2021. Publisher Copyright: {\textcopyright} 2022 American Academy of Allergy, Asthma & Immunology",
year = "2022",
month = dec,
doi = "10.1016/j.jaip.2022.09.020",
language = "English (US)",
volume = "10",
pages = "3075--3086",
journal = "Journal of Allergy and Clinical Immunology: In Practice",
issn = "2213-2198",
publisher = "Elsevier",
number = "12",
}