A rapidly occurring compensatory decrease in physical activity counteracts diet-induced weight loss in female monkeys

Elinor Sullivan, Judy L. Cameron

    Research output: Contribution to journalArticle

    23 Citations (Scopus)

    Abstract

    To study changes in energy balance occurring during the initial phases of dieting, 18 adult ovariectomized female monkeys were placed on a low-fat diet, and available calories were reduced by 30% compared with baseline consumption for 1 mo. Surprisingly, there was not significant weight loss; however, daily activity level (measured by accelerometry) decreased soon after diet initiation and reached statistical significance by the 4th wk of dieting (18 ± 5.6% decrease, P = 0.02). During a 2nd mo of dieting, available calories were reduced by 60% compared with baseline consumption, leading to 6.4 ± 1.7% weight loss and further suppression of activity. Metabolic rate decreased by 68 ± 12 kcal/day, with decreased activity accounting for 41 ± 9 kcal/day, and the metabolic activity of the weight lost accounting for 21 ± 5 kcal/day. A second group of three monkeys was trained to run on a treadmill for 1 h/day, 5 days/wk, at 80% maximal capacity, leading to increased calorie expenditure of 69.6 ± 10.7 kcal/day (equivalent to 49 kcal/day for 7 days). We conclude that a diet-induced decrease in physical activity is the primary mechanism the body uses to defend against diet-induced weight loss, and undertaking a level of exercise that is recommended to counteract weight gain and promote weight loss is able to prevent the compensatory decrease in physical activity-associated energy expenditure that slows diet-induced weight loss.

    Original languageEnglish (US)
    JournalAmerican Journal of Physiology - Regulatory Integrative and Comparative Physiology
    Volume298
    Issue number4
    DOIs
    StatePublished - Apr 2010

    Fingerprint

    Reducing Diet
    Haplorhini
    Weight Loss
    Accelerometry
    Diet
    Fat-Restricted Diet
    Health Expenditures
    Energy Metabolism
    Weight Gain
    Weights and Measures

    Keywords

    • Activity
    • Calorie reduction
    • Obesity

    ASJC Scopus subject areas

    • Physiology
    • Physiology (medical)

    Cite this

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    abstract = "To study changes in energy balance occurring during the initial phases of dieting, 18 adult ovariectomized female monkeys were placed on a low-fat diet, and available calories were reduced by 30{\%} compared with baseline consumption for 1 mo. Surprisingly, there was not significant weight loss; however, daily activity level (measured by accelerometry) decreased soon after diet initiation and reached statistical significance by the 4th wk of dieting (18 ± 5.6{\%} decrease, P = 0.02). During a 2nd mo of dieting, available calories were reduced by 60{\%} compared with baseline consumption, leading to 6.4 ± 1.7{\%} weight loss and further suppression of activity. Metabolic rate decreased by 68 ± 12 kcal/day, with decreased activity accounting for 41 ± 9 kcal/day, and the metabolic activity of the weight lost accounting for 21 ± 5 kcal/day. A second group of three monkeys was trained to run on a treadmill for 1 h/day, 5 days/wk, at 80{\%} maximal capacity, leading to increased calorie expenditure of 69.6 ± 10.7 kcal/day (equivalent to 49 kcal/day for 7 days). We conclude that a diet-induced decrease in physical activity is the primary mechanism the body uses to defend against diet-induced weight loss, and undertaking a level of exercise that is recommended to counteract weight gain and promote weight loss is able to prevent the compensatory decrease in physical activity-associated energy expenditure that slows diet-induced weight loss.",
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