A randomized placebo-controlled study of noninvasive cortical electrostimulation in the treatment of fibromyalgia patients

Jeffrey B. Hargrove, Robert (Rob) Bennett, David G. Simons, Susan J. Smith, Sunil Nagpal, Donald E. Deering

    Research output: Contribution to journalArticle

    12 Citations (Scopus)

    Abstract

    Objective. The aim of this multicenter study was to evaluate the efficacy, safety, and tolerability of noninvasive cortical electrostimulation in the management of fibromyalgia (FM). Design. A prospective, randomized, double-blind, placebo-controlled design was used. Setting. Subjects received therapy at two different outpatient clinical locations. Patients. There were 77 subjects meeting the American College of Rheumatology 1990 classification criteria for FM. Intervention. Thirty-nine (39) active treatment (AT) FM patients and 38 placebo controls received 22 applications of either noninvasive cortical electrostimulation or a sham therapy over an 11-week period. Outcome Measures. The primary outcome measures were the number of tender points (TePs) and pressure pain threshold (PPT). Secondary outcome measures were responses to the Fibromyalgia Impact Questionnaire (FIQ), Symptom Checklist-90 (SCL-90), Beck Depression Inventory-II, and a novel sleep questionnaire, all evaluated at baseline and at the end of treatment. Results. Intervention provided significant improvements in TeP measures: compared with placebo, the AT patients improved in the number of positive TePs (-7.4 vs -0.2, P

    Original languageEnglish (US)
    Pages (from-to)115-124
    Number of pages10
    JournalPain Medicine
    Volume13
    Issue number1
    DOIs
    StatePublished - Jan 2012

    Fingerprint

    Fibromyalgia
    Placebos
    Outcome Assessment (Health Care)
    Therapeutics
    Pain Threshold
    Checklist
    Multicenter Studies
    Sleep
    Outpatients
    Depression
    Safety
    Pressure
    Equipment and Supplies

    Keywords

    • Cortical
    • Electrical
    • Fibromyalgia
    • Noninvasive
    • Pain management
    • Stimulation

    ASJC Scopus subject areas

    • Clinical Neurology
    • Anesthesiology and Pain Medicine

    Cite this

    A randomized placebo-controlled study of noninvasive cortical electrostimulation in the treatment of fibromyalgia patients. / Hargrove, Jeffrey B.; Bennett, Robert (Rob); Simons, David G.; Smith, Susan J.; Nagpal, Sunil; Deering, Donald E.

    In: Pain Medicine, Vol. 13, No. 1, 01.2012, p. 115-124.

    Research output: Contribution to journalArticle

    Hargrove, Jeffrey B. ; Bennett, Robert (Rob) ; Simons, David G. ; Smith, Susan J. ; Nagpal, Sunil ; Deering, Donald E. / A randomized placebo-controlled study of noninvasive cortical electrostimulation in the treatment of fibromyalgia patients. In: Pain Medicine. 2012 ; Vol. 13, No. 1. pp. 115-124.
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