A preliminary examination of how serotonergic polymorphisms influence brain response following an adolescent cannabis intervention

Sarah W. Feldstein Ewing; Hilary K. Mead; Uma Yezhuvath; Sam DeWitt; Kent E. Hutchison; Francesca M. Filbey

doi:10.1016/j.pscychresns.2012.10.011

A preliminary examination of how serotonergic polymorphisms influence brain response following an adolescent cannabis intervention

Sarah W. Feldstein Ewing, Hilary K. Mead, Uma Yezhuvath, Sam DeWitt, Kent E. Hutchison, Francesca M. Filbey

Research output: Contribution to journal › Article › peer-review

16 Scopus citations

Abstract

Given the link between depression, anxiety, and cannabis abuse, a serotonin receptor (rs6311) and transporter polymorphism (rs2020936) were examined as moderators of neural response as measured by functional magnetic resonance imaging following a psychosocial treatment for cannabis use disorders (CUDs). While the proposed hypotheses were unsupported, we found that the rs6311 C allele was significantly related to brain activation (medial frontal gyrus, precuneus), indicating the role of this serotonin receptor in adolescent treatment response.

Original language	English (US)
Pages (from-to)	112-116
Number of pages	5
Journal	Psychiatry Research - Neuroimaging
Volume	204
Issue number	2-3
DOIs	https://doi.org/10.1016/j.pscychresns.2012.10.011
State	Published - Nov 30 2012
Externally published	Yes

Keywords

Adolescents
Cannabis
Client language
FMRI
Genetics

ASJC Scopus subject areas

Neuroscience (miscellaneous)
Radiology Nuclear Medicine and imaging
Psychiatry and Mental health

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10.1016/j.pscychresns.2012.10.011

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abstract = "Given the link between depression, anxiety, and cannabis abuse, a serotonin receptor (rs6311) and transporter polymorphism (rs2020936) were examined as moderators of neural response as measured by functional magnetic resonance imaging following a psychosocial treatment for cannabis use disorders (CUDs). While the proposed hypotheses were unsupported, we found that the rs6311 C allele was significantly related to brain activation (medial frontal gyrus, precuneus), indicating the role of this serotonin receptor in adolescent treatment response.",

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AU - DeWitt, Sam

AU - Hutchison, Kent E.

AU - Filbey, Francesca M.

PY - 2012/11/30

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AB - Given the link between depression, anxiety, and cannabis abuse, a serotonin receptor (rs6311) and transporter polymorphism (rs2020936) were examined as moderators of neural response as measured by functional magnetic resonance imaging following a psychosocial treatment for cannabis use disorders (CUDs). While the proposed hypotheses were unsupported, we found that the rs6311 C allele was significantly related to brain activation (medial frontal gyrus, precuneus), indicating the role of this serotonin receptor in adolescent treatment response.

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KW - Cannabis

KW - Client language

KW - FMRI

KW - Genetics

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A preliminary examination of how serotonergic polymorphisms influence brain response following an adolescent cannabis intervention

Abstract

Keywords

ASJC Scopus subject areas

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