A preliminary examination of how serotonergic polymorphisms influence brain response following an adolescent cannabis intervention

Sarah W. Feldstein Ewing, Hilary K. Mead, Uma Yezhuvath, Sam DeWitt, Kent E. Hutchison, Francesca M. Filbey

Research output: Contribution to journalArticle

14 Scopus citations

Abstract

Given the link between depression, anxiety, and cannabis abuse, a serotonin receptor (rs6311) and transporter polymorphism (rs2020936) were examined as moderators of neural response as measured by functional magnetic resonance imaging following a psychosocial treatment for cannabis use disorders (CUDs). While the proposed hypotheses were unsupported, we found that the rs6311 C allele was significantly related to brain activation (medial frontal gyrus, precuneus), indicating the role of this serotonin receptor in adolescent treatment response.

Original languageEnglish (US)
Pages (from-to)112-116
Number of pages5
JournalPsychiatry Research - Neuroimaging
Volume204
Issue number2-3
DOIs
StatePublished - Nov 30 2012

Keywords

  • Adolescents
  • Cannabis
  • Client language
  • FMRI
  • Genetics

ASJC Scopus subject areas

  • Neuroscience (miscellaneous)
  • Radiology Nuclear Medicine and imaging
  • Psychiatry and Mental health

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