Abstract
Background. Familial male precocious puyityis a gonadotropin-independent form of precocious puberty that occurs only in males. The cause of the disorder is unknown. To examine the hypothesis that the plasma of boys with familial male precocious puberty contains a novel stimulator of testicular testosterone production, we developed a bioassay using adult male cynomolgus monkeys. Methods. We collected plasma from 12 boys with familial male precocious puberty, 7 normal prepubertal boys of similar ages and with similar plasma gonadotropin levels, and 1 boy with hypogonadotropic hypogonadism and infused it into the testicular artery of adult male cynomolgus monkeys that had been pretreated with gonadotropin-releasing-hormone antagonist to inhibit the endogenous secretion of gonadotropins. Testicular venous effluent was collected at 15-minute intervals for 3 or 5 hours for the measurement of testosterone. Results. The mean (±SE) peak testosterone response, as compared with base line, was significantly greater in the monkeys infused with plasma from the 12 toys with familial male precocious puberty than in the monkeys infused with plasma from the 7 normal prepubertal boys and the boy with hypogonadotropic hypogonadism (385±51 vs. 184±25 percent, P
| Original language | English (US) |
|---|---|
| Pages (from-to) | 227-231 |
| Number of pages | 5 |
| Journal | New England Journal of Medicine |
| Volume | 324 |
| Issue number | 4 |
| State | Published - Jan 24 1991 |
| Externally published | Yes |
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ASJC Scopus subject areas
- Medicine(all)
Cite this
A novel testis-stimulating factor in familial male precocious puberty. / Manasco, Penelope K.; Girton, Mary E.; Diggs, Richard L.; Doppman, John L.; Loriaux, Donald (Lynn); Barnes, Kevin M.; Cutler, Gordon B.; Loriaux, D. Lynn; Albertson, Barry D.
In: New England Journal of Medicine, Vol. 324, No. 4, 24.01.1991, p. 227-231.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - A novel testis-stimulating factor in familial male precocious puberty
AU - Manasco, Penelope K.
AU - Girton, Mary E.
AU - Diggs, Richard L.
AU - Doppman, John L.
AU - Loriaux, Donald (Lynn)
AU - Barnes, Kevin M.
AU - Cutler, Gordon B.
AU - Loriaux, D. Lynn
AU - Albertson, Barry D.
PY - 1991/1/24
Y1 - 1991/1/24
N2 - Background. Familial male precocious puyityis a gonadotropin-independent form of precocious puberty that occurs only in males. The cause of the disorder is unknown. To examine the hypothesis that the plasma of boys with familial male precocious puberty contains a novel stimulator of testicular testosterone production, we developed a bioassay using adult male cynomolgus monkeys. Methods. We collected plasma from 12 boys with familial male precocious puberty, 7 normal prepubertal boys of similar ages and with similar plasma gonadotropin levels, and 1 boy with hypogonadotropic hypogonadism and infused it into the testicular artery of adult male cynomolgus monkeys that had been pretreated with gonadotropin-releasing-hormone antagonist to inhibit the endogenous secretion of gonadotropins. Testicular venous effluent was collected at 15-minute intervals for 3 or 5 hours for the measurement of testosterone. Results. The mean (±SE) peak testosterone response, as compared with base line, was significantly greater in the monkeys infused with plasma from the 12 toys with familial male precocious puberty than in the monkeys infused with plasma from the 7 normal prepubertal boys and the boy with hypogonadotropic hypogonadism (385±51 vs. 184±25 percent, P
AB - Background. Familial male precocious puyityis a gonadotropin-independent form of precocious puberty that occurs only in males. The cause of the disorder is unknown. To examine the hypothesis that the plasma of boys with familial male precocious puberty contains a novel stimulator of testicular testosterone production, we developed a bioassay using adult male cynomolgus monkeys. Methods. We collected plasma from 12 boys with familial male precocious puberty, 7 normal prepubertal boys of similar ages and with similar plasma gonadotropin levels, and 1 boy with hypogonadotropic hypogonadism and infused it into the testicular artery of adult male cynomolgus monkeys that had been pretreated with gonadotropin-releasing-hormone antagonist to inhibit the endogenous secretion of gonadotropins. Testicular venous effluent was collected at 15-minute intervals for 3 or 5 hours for the measurement of testosterone. Results. The mean (±SE) peak testosterone response, as compared with base line, was significantly greater in the monkeys infused with plasma from the 12 toys with familial male precocious puberty than in the monkeys infused with plasma from the 7 normal prepubertal boys and the boy with hypogonadotropic hypogonadism (385±51 vs. 184±25 percent, P
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M3 - Article
C2 - 1898671
AN - SCOPUS:0026063964
VL - 324
SP - 227
EP - 231
JO - New England Journal of Medicine
JF - New England Journal of Medicine
SN - 0028-4793
IS - 4
ER -