TY - JOUR
T1 - A neonatal nonhuman primate model of gestational Zika virus infection with evidence of microencephaly, seizures and cardiomyopathy
AU - Steinbach, Rosemary J.
AU - Haese, Nicole N.
AU - Smith, Jessica L.
AU - Colgin, Lois M.A.
AU - MacAllister, Rhonda P.
AU - Greene, Justin M.
AU - Parkins, Christopher J.
AU - Kempton, J. Beth
AU - Porsov, Edward
AU - Wang, Xiaojie
AU - Renner, Lauren M.
AU - McGill, Trevor J.
AU - Dozier, Brandy L.
AU - Kreklywich, Craig N.
AU - Andoh, Takeshi F.
AU - Grafe, Marjorie R.
AU - Pecoraro, Heidi L.
AU - Hodge, Travis
AU - Friedman, Robert M.
AU - Houser, Lisa A.
AU - Morgan, Terry K.
AU - Stenzel, Peter
AU - Lindner, Jonathan R.
AU - Schelonka, Robert L.
AU - Sacha, Jonah B.
AU - Roberts, Victoria H.J.
AU - Neuringer, Martha
AU - Brigande, John V.
AU - Kroenke, Christopher D.
AU - Frias, Antonio E.
AU - Lewis, Anne D.
AU - Kelleher, Meredith A.
AU - Hirsch, Alec J.
AU - Streblow, Daniel Neal
PY - 2020
Y1 - 2020
N2 - Zika virus infection during pregnancy is associated with miscarriage and with a broad spectrum of fetal and neonatal developmental abnormalities collectively known as congenital Zika syndrome (CZS). Symptomology of CZS includes malformations of the brain and skull, neurodevelopmental delay, seizures, joint contractures, hearing loss and visual impairment. Previous studies of Zika virus in pregnant rhesus macaques (Macaca mulatta) have described injury to the developing fetus and pregnancy loss, but neonatal outcomes following fetal Zika virus exposure have yet to be characterized in nonhuman primates. Herein we describe the presentation of rhesus macaque neonates with a spectrum of clinical outcomes, including one infant with CZS-like symptoms including cardiomyopathy, motor delay and seizure activity following maternal infection with Zika virus during the first trimester of pregnancy. Further characterization of this neonatal nonhuman primate model of gestational Zika virus infection will provide opportunities to evaluate the efficacy of pre- and postnatal therapeutics for gestational Zika virus infection and CZS.
AB - Zika virus infection during pregnancy is associated with miscarriage and with a broad spectrum of fetal and neonatal developmental abnormalities collectively known as congenital Zika syndrome (CZS). Symptomology of CZS includes malformations of the brain and skull, neurodevelopmental delay, seizures, joint contractures, hearing loss and visual impairment. Previous studies of Zika virus in pregnant rhesus macaques (Macaca mulatta) have described injury to the developing fetus and pregnancy loss, but neonatal outcomes following fetal Zika virus exposure have yet to be characterized in nonhuman primates. Herein we describe the presentation of rhesus macaque neonates with a spectrum of clinical outcomes, including one infant with CZS-like symptoms including cardiomyopathy, motor delay and seizure activity following maternal infection with Zika virus during the first trimester of pregnancy. Further characterization of this neonatal nonhuman primate model of gestational Zika virus infection will provide opportunities to evaluate the efficacy of pre- and postnatal therapeutics for gestational Zika virus infection and CZS.
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U2 - 10.1371/journal.pone.0227676
DO - 10.1371/journal.pone.0227676
M3 - Article
C2 - 31935257
AN - SCOPUS:85077872045
SN - 1932-6203
VL - 15
SP - e0227676
JO - PLoS One
JF - PLoS One
IS - 1
ER -