@article{8c390392aa964451972f7c1d878bd009,
title = "A multicenter randomized controlled trial of two group education programs for fatigue in multiple sclerosis: Long-term (12-month) follow-up at one site",
abstract = "Background: A four-site RCT of Fatigue: Take Control (FTC), a multicomponent group program, found no significant differences from a control program, MS: Take Control (MSTC), in fatigue on the Modified Fatigue Impact Scale (MFIS) through 6 months. Objective: Assess FTC for a delayed effect on fatigue. Methods: Of 78 subjects at one site, 74 randomized to FTC or MSTC completed the MFIS at 12 months. Results: Compared to baseline, FTC produced greater improvements in MFIS scores than MSTC (FTC −8.9 (confidence interval (CI): 32.2, 45), MSTC −2.5 (CI 39.6, 47.7), p = 0.03) at 12 months. Conclusion: The delayed effect of FTC on fatigue suggests the need for longer follow-up when assessing interventions for fatigue.",
keywords = "Multiple sclerosis, clinical trial, fatigue, rehabilitation, self-care, symptom management",
author = "Hugos, {Cinda L.} and Cameron, {Michelle H.} and Zunqiu Chen and Yiyi Chen and Dennis Bourdette",
note = "Funding Information: Thank you to all our participants, Lois Copperman co-creator of Fatigue: Take Control (FTC) and our Data Safety Monitoring Board in Portland: Ruth Whitham, MD, (Chair) Joe Quinn, MD, and Cynthia Morris, PhD. C.L.H., M.H.C., Z.C., Y.C., and D.B. contributed equally to this manuscript. Zunqiu Chen, MS, and Yiyi Chen, PhD, both at Oregon Health and Sciences University, conducted the statistical analysis. ClinicalTrials.gov identifier: NCT01918800. The authors thank the following contributors: Kristina Wick, MPH, CCRP (overall study and local site coordinator), Elizabeth Heriza, MD (study coordinator), Carol Choutka (Fatigue: Take Control (FTC) facilitator), and Kim Southworth (MS: Take Control (MSTC) facilitator). The author(s) disclosed receipt of the following financial support for the research, authorship, and/or publication of this article: Funding was provided by VA Office of Research and Development (F7777-R) and Oregon Clinical and Translational Research Institute (OCTRI; National Center for Advancing Translational Science (NCATS)-funded Clinical and Translational Science Awards (CTSA) grant UL1TR000128). Funding Information: The author(s) disclosed receipt of the following financial support for the research, authorship, and/or publication of this article: Funding was provided by VA Office of Research and Development (F7777-R) and Oregon Clinical and Translational Research Institute (OCTRI; National Center for Advancing Translational Science (NCATS)-funded Clinical and Translational Science Awards (CTSA) grant UL1TR000128). Publisher Copyright: {\textcopyright} The Author(s), 2018.",
year = "2019",
month = may,
day = "1",
doi = "10.1177/1352458518775920",
language = "English (US)",
volume = "25",
pages = "871--875",
journal = "Multiple Sclerosis",
issn = "1352-4585",
publisher = "SAGE Publications Ltd",
number = "6",
}