A multicenter randomized controlled trial of two group education programs for fatigue in multiple sclerosis: Long-term (12-month) follow-up at one site

Cinda L. Hugos, Michelle H. Cameron, Zunqiu Chen, Yiyi Chen, Dennis Bourdette

Research output: Contribution to journalArticle

1 Scopus citations

Abstract

Background: A four-site RCT of Fatigue: Take Control (FTC), a multicomponent group program, found no significant differences from a control program, MS: Take Control (MSTC), in fatigue on the Modified Fatigue Impact Scale (MFIS) through 6 months. Objective: Assess FTC for a delayed effect on fatigue. Methods: Of 78 subjects at one site, 74 randomized to FTC or MSTC completed the MFIS at 12 months. Results: Compared to baseline, FTC produced greater improvements in MFIS scores than MSTC (FTC −8.9 (confidence interval (CI): 32.2, 45), MSTC −2.5 (CI 39.6, 47.7), p = 0.03) at 12 months. Conclusion: The delayed effect of FTC on fatigue suggests the need for longer follow-up when assessing interventions for fatigue.

Original languageEnglish (US)
Pages (from-to)871-875
Number of pages5
JournalMultiple Sclerosis Journal
Volume25
Issue number6
DOIs
StatePublished - May 1 2019

Keywords

  • Multiple sclerosis
  • clinical trial
  • fatigue
  • rehabilitation
  • self-care
  • symptom management

ASJC Scopus subject areas

  • Neurology
  • Clinical Neurology

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