TY - JOUR
T1 - A mechanism for active hearing
AU - Ren, Tianying
AU - Gillespie, Peter G.
N1 - Funding Information:
Work in the authors’ laboratories is supported by the National Institute of Deafness and Other Communication Disorders.
PY - 2007/8
Y1 - 2007/8
N2 - The remarkable sensitivity, frequency selectivity, and nonlinearity of the cochlea have been attributed to the putative 'cochlear amplifier', which consumes metabolic energy to amplify the cochlear mechanical response to sounds. Recent studies have demonstrated that outer hair cells actively generate force using somatic electromotility and active hair-bundle motion. However, the expected power gain of the cochlear amplifier has not been demonstrated experimentally, and the measured location of cochlear nonlinearity is inconsistent with the predicted location of the cochlear amplifier. We instead propose a 'cochlear transformer' mechanism to interpret cochlear performance.
AB - The remarkable sensitivity, frequency selectivity, and nonlinearity of the cochlea have been attributed to the putative 'cochlear amplifier', which consumes metabolic energy to amplify the cochlear mechanical response to sounds. Recent studies have demonstrated that outer hair cells actively generate force using somatic electromotility and active hair-bundle motion. However, the expected power gain of the cochlear amplifier has not been demonstrated experimentally, and the measured location of cochlear nonlinearity is inconsistent with the predicted location of the cochlear amplifier. We instead propose a 'cochlear transformer' mechanism to interpret cochlear performance.
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U2 - 10.1016/j.conb.2007.07.013
DO - 10.1016/j.conb.2007.07.013
M3 - Review article
C2 - 17707636
AN - SCOPUS:34948879653
SN - 0959-4388
VL - 17
SP - 498
EP - 503
JO - Current Opinion in Neurobiology
JF - Current Opinion in Neurobiology
IS - 4
ER -