A maternal high-fat diet is accompanied by alterations in the fetal primate metabolome

James Cox, Sarah Williams, Kevin Grove, Robert H. Lane, Kjersti M. Aagaard-Tillery

    Research output: Contribution to journalArticle

    40 Citations (Scopus)

    Abstract

    Objective: To characterize the serum metabolome of a primate model of in utero high-fat exposure. Study Design: Serum from maternal and fetal (e130) macaque monkeys exposed to either a high-fat or control diet were analyzed by gas chromatography-mass spectrometry. Multivariate data analysis was performed to reduce the generated data set. Candidate metabolites were further analyzed for significance by using the analysis of variance and comparative t tests. Results: Approximately 1300 chromatographic features were detected. Through multivariate data analysis this number was reduced to 60 possible metabolites. With the use of comparative t tests, 22 metabolites had statistical significance (P <.05) over the entire study. By virtue of maternal high-fat diet alone, fetal phenotypic differences are accompanied by altered metabolite concentrations of 7 metabolites (P <.05). Conclusion: In utero high-fat diet exposure is associated with an altered fetal epigenome and parlays a characteristic modification in the fetal metabolite profile.

    Original languageEnglish (US)
    JournalAmerican Journal of Obstetrics and Gynecology
    Volume201
    Issue number3
    DOIs
    StatePublished - Sep 2009

    Fingerprint

    Metabolome
    High Fat Diet
    Primates
    Multivariate Analysis
    Fats
    Mothers
    Macaca
    Serum
    Gas Chromatography-Mass Spectrometry
    Haplorhini
    Analysis of Variance
    Diet
    Datasets

    Keywords

    • epigenetics
    • fetal programming
    • metabolomics
    • nutrition
    • obesity
    • pregnancy

    ASJC Scopus subject areas

    • Obstetrics and Gynecology

    Cite this

    A maternal high-fat diet is accompanied by alterations in the fetal primate metabolome. / Cox, James; Williams, Sarah; Grove, Kevin; Lane, Robert H.; Aagaard-Tillery, Kjersti M.

    In: American Journal of Obstetrics and Gynecology, Vol. 201, No. 3, 09.2009.

    Research output: Contribution to journalArticle

    Cox, James ; Williams, Sarah ; Grove, Kevin ; Lane, Robert H. ; Aagaard-Tillery, Kjersti M. / A maternal high-fat diet is accompanied by alterations in the fetal primate metabolome. In: American Journal of Obstetrics and Gynecology. 2009 ; Vol. 201, No. 3.
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