A double-blind, randomized, bilateral comparison of skin irritancy following application of the combination acne products clindamycin/tretinoin and benzoyl peroxide/adapalene

Renato Goreshi, Aman Samrao, Benjamin (Ben) Ehst

Research output: Contribution to journalArticle

8 Citations (Scopus)

Abstract

Background: The use of topical medications for acne vulgaris is often limited by their irritant properties. Newer combination preparations are available and offer convenience, but irritant potential may still be a hindrance, perhaps more so with the combination of 2 agents. Few studies have compared these formulations directly for tolerability. Objective: We sought to compare the tolerability of 2 combination topical acne products, clindamycin 1.2%-tretinoin 0.025% (CLIN/RA) gel and benzoyl peroxide 2.5%-adapalene 0.1% (BPO/ADA) gel. Methods: CLIN/RA and BPO/ADA were applied daily to opposite sides of a subject's face for 21 days in a double-blinded fashion. Investigators' Global Assessments and study subject self-assessments of burning/stinging, itching, erythema, and dryness/scaling were collected. Transepidermal water loss (TEWL) was also measured as an objective measure of skin irritation. A mixed model analysis and repeated-measures analysis of variance were used to compare outcomes for both acne formulations. Results: CLIN/RA produced significantly less burning/stinging than BPO/ADA (P

Original languageEnglish (US)
Pages (from-to)1422-1426
Number of pages5
JournalJournal of Drugs in Dermatology
Volume11
Issue number12
StatePublished - Dec 2012

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Benzoyl Peroxide
Acne Vulgaris
Irritants
Skin
Gels
Erythema
Pruritus
Analysis of Variance
Research Personnel
Water
Adapalene
tretinoin drug combination clindamycin

ASJC Scopus subject areas

  • Dermatology

Cite this

A double-blind, randomized, bilateral comparison of skin irritancy following application of the combination acne products clindamycin/tretinoin and benzoyl peroxide/adapalene. / Goreshi, Renato; Samrao, Aman; Ehst, Benjamin (Ben).

In: Journal of Drugs in Dermatology, Vol. 11, No. 12, 12.2012, p. 1422-1426.

Research output: Contribution to journalArticle

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