A delayed injection-site reaction in a patient receiving extended-release naltrexone

Keith Ahamad, Philip (Todd) Korthuis, Paula J. Lum, Cheyenne Johnson, Evan Wood

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

Background: Pharmacotherapy, such as oral naltrexone, has proven effective in treating alcohol use disorder, although medication adherence has presented challenges. Although a formulation of extended-release naltrexone for intramuscular injection has been developed to counter daily adherence issues, injection-site reactions can occur within days of depot injection. Case: The authors report a case of an individual with alcohol use disorder who had a previously undescribed delayed injection-site reaction that occurred 11 days after injection. Subsequent challenge with the medication resulted in recurrence of the reaction. Discussion: Although extended-release naltrexone is generally well tolerated, injection-site reactions can complicate treatment and can appear more than 10 days after medication administration.

Original languageEnglish (US)
Pages (from-to)278-280
Number of pages3
JournalSubstance Abuse
Volume37
Issue number2
DOIs
StatePublished - Apr 2 2016

Fingerprint

Naltrexone
Injections
Alcohols
Medication Adherence
Intramuscular Injections
Recurrence
Drug Therapy

Keywords

  • Alcohol use disorder
  • extended-release naltrexone
  • injection-site reaction

ASJC Scopus subject areas

  • Medicine (miscellaneous)
  • Psychiatry and Mental health

Cite this

A delayed injection-site reaction in a patient receiving extended-release naltrexone. / Ahamad, Keith; Korthuis, Philip (Todd); Lum, Paula J.; Johnson, Cheyenne; Wood, Evan.

In: Substance Abuse, Vol. 37, No. 2, 02.04.2016, p. 278-280.

Research output: Contribution to journalArticle

Ahamad, Keith ; Korthuis, Philip (Todd) ; Lum, Paula J. ; Johnson, Cheyenne ; Wood, Evan. / A delayed injection-site reaction in a patient receiving extended-release naltrexone. In: Substance Abuse. 2016 ; Vol. 37, No. 2. pp. 278-280.
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