@article{1769111531414c428353a5736c8c668f,
title = "A cytosolic herpes simplex virus protein inhibits antigen presentation to CD8+ T lymphocytes",
abstract = "Herpes simplex virus (HSV) infection of human fibroblasts rapidly renders the cells resistant to lysis by HSV-specific CD8+ cytotoxic T lymphocytes (CTLs), which normally recognize cell surface major histocompatibility complex (MHC) class I proteins presenting viral peptides. Within 3 hr of infection with HSV, MHC class I protein complexes are retained in the endoplasmic reticulum (ER)/cis Golgi and show properties of complexes lacking antigenic peptide. The HSV immediate-early protein ICP47 is both necessary and sufficient to block transport of class I proteins and to inhibit lysis by CD8+ CTLs. The target for ICP47 is not known, but since ICP47 does not associate with membranes, it appears that ICP47 inhibits the production or stabilization of antigenic peptides or their translocation into the ER/cis Golgi. Thus, by expressing ICP47, HSV can evade detection by CD8+ T lymphocytes, perhaps explaining the predominance of CD4+ rather than CD8+ HSV-specific CTLs in vivo.",
author = "York, {Ian A.} and Cindy Roop and Andrews, {David W.} and Riddell, {Stanley R.} and Graham, {Frank L.} and Johnson, {David C.}",
note = "Funding Information: Correspondence should be addressed to D. C. J. We thank Hidde Ploegh, Tony Minson. Brian Barber, Thomas Spies, and Howard Mars-den for generous giftsof antibodies; Wilfred Jefferiesfor plasmids and advice; Laurie Doering for help with immunofluorescence experiments; Christine Addison for pCA4; and Dan Vesperini and John Rudy for excellent technical assistance. We are especially indebted to Jim Smiley for insights and support throughout this work and to Michael Tigges and Rae Lyn Burke for helpful discussions and for sharing unpublisheddata.Thisworkwassupported bygrantsfrom the National Cancer Institute of Canada (NCIC), the Medical Research Council of Canada (MRC), the Natural Sciences and Engineering Research Council of Canada, and grant CA15029 from the National Institutes of Health. D. C. J. is an NCIC senior research scientist, F. L. G. is an NCIC Terry Fox senior research scientist, D. W. A. holds an MRC research fellowship, and S. R. R. is supported by a Partridge Foundation Investigator Award from the Cancer Research Institute.",
year = "1994",
month = may,
day = "20",
doi = "10.1016/0092-8674(94)90215-1",
language = "English (US)",
volume = "77",
pages = "525--535",
journal = "Cell",
issn = "0092-8674",
publisher = "Cell Press",
number = "4",
}