A cytosolic herpes simplex virus protein inhibits antigen presentation to CD8+ T lymphocytes

Ian A. York, Cindy Roop, David W. Andrews, Stanley R. Riddell, Frank L. Graham, David Johnson

Research output: Contribution to journalArticle

429 Citations (Scopus)

Abstract

Herpes simplex virus (HSV) infection of human fibroblasts rapidly renders the cells resistant to lysis by HSV-specific CD8+ cytotoxic T lymphocytes (CTLs), which normally recognize cell surface major histocompatibility complex (MHC) class I proteins presenting viral peptides. Within 3 hr of infection with HSV, MHC class I protein complexes are retained in the endoplasmic reticulum (ER)/cis Golgi and show properties of complexes lacking antigenic peptide. The HSV immediate-early protein ICP47 is both necessary and sufficient to block transport of class I proteins and to inhibit lysis by CD8+ CTLs. The target for ICP47 is not known, but since ICP47 does not associate with membranes, it appears that ICP47 inhibits the production or stabilization of antigenic peptides or their translocation into the ER/cis Golgi. Thus, by expressing ICP47, HSV can evade detection by CD8+ T lymphocytes, perhaps explaining the predominance of CD4+ rather than CD8+ HSV-specific CTLs in vivo.

Original languageEnglish (US)
Pages (from-to)525-535
Number of pages11
JournalCell
Volume77
Issue number4
DOIs
StatePublished - May 20 1994
Externally publishedYes

Fingerprint

T-cells
Antigen Presentation
Simplexvirus
Viruses
T-Lymphocytes
Antigens
Cytotoxic T-Lymphocytes
Proteins
Major Histocompatibility Complex
Endoplasmic Reticulum
Peptides
Immediate-Early Proteins
Viral Proteins
Virus Diseases
Fibroblasts
Stabilization
Membranes
Infection

ASJC Scopus subject areas

  • Cell Biology
  • Molecular Biology

Cite this

A cytosolic herpes simplex virus protein inhibits antigen presentation to CD8+ T lymphocytes. / York, Ian A.; Roop, Cindy; Andrews, David W.; Riddell, Stanley R.; Graham, Frank L.; Johnson, David.

In: Cell, Vol. 77, No. 4, 20.05.1994, p. 525-535.

Research output: Contribution to journalArticle

York, Ian A. ; Roop, Cindy ; Andrews, David W. ; Riddell, Stanley R. ; Graham, Frank L. ; Johnson, David. / A cytosolic herpes simplex virus protein inhibits antigen presentation to CD8+ T lymphocytes. In: Cell. 1994 ; Vol. 77, No. 4. pp. 525-535.
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