A Comprehensive Review of Local Pharmacologic Therapy for Pyoderma Gangrenosum

David Baltazar, Carter Haag, Angela S. Gupta, Angelo Marzano Marzano, Alex Ortega Loayza

Research output: Contribution to journalArticle

Abstract

Pyoderma gangrenosum (PG) is a rare, ulcerative inflammatory skin disease that most commonly occurs in patients with inflammatory bowel disease, rheumatologic diseases, or hematologic diseases. Successful treatment of PG often requires immunosuppression and appropriate wound care. Systemic corticosteroids and cyclosporine are the first-line treatments for PG. However, chronic use of these systemic agents places patients at risk for developing significant side effects, including hyperglycemia, osteoporosis, hypertension, and weight gain. Furthermore, when treating small or superficial PG ulcers, the use of local agents as monotherapies or adjuvant treatments can be ideal to control inflammation and promote healing without placing the patient at risk for many severe side effects that can be seen with long-term use of systemic agents. This literature review assesses all available local therapies in order to summarize the use and reported efficaciousness of the broad range of local treatments available for PG.

Original languageEnglish (US)
Pages (from-to)151-157
Number of pages7
JournalWounds : a compendium of clinical research and practice
Volume31
Issue number6
StatePublished - Jun 1 2019

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Pyoderma Gangrenosum
Therapeutics
Hematologic Diseases
Proxy
Inflammatory Bowel Diseases
Skin Diseases
Hyperglycemia
Immunosuppression
Cyclosporine
Osteoporosis
Ulcer
Weight Gain
Adrenal Cortex Hormones
Hypertension
Inflammation
Wounds and Injuries

ASJC Scopus subject areas

  • Surgery
  • Medical–Surgical

Cite this

A Comprehensive Review of Local Pharmacologic Therapy for Pyoderma Gangrenosum. / Baltazar, David; Haag, Carter; Gupta, Angela S.; Marzano, Angelo Marzano; Ortega Loayza, Alex.

In: Wounds : a compendium of clinical research and practice, Vol. 31, No. 6, 01.06.2019, p. 151-157.

Research output: Contribution to journalArticle

Baltazar, David ; Haag, Carter ; Gupta, Angela S. ; Marzano, Angelo Marzano ; Ortega Loayza, Alex. / A Comprehensive Review of Local Pharmacologic Therapy for Pyoderma Gangrenosum. In: Wounds : a compendium of clinical research and practice. 2019 ; Vol. 31, No. 6. pp. 151-157.
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