A composite spheres analysis of engineered cartilage mechanics

Sean S. Kohles, Christopher G. Wilson, Lawrence J. Bonassar

Research output: Chapter in Book/Report/Conference proceedingConference contribution

1 Scopus citations

Abstract

In the preparation of bioengineered reparative strategies for damaged or diseased tissues, the processes of biomaterial degeneration and neotissue synthesis combine to affect the developing mechanical state of multi-phase, composite engineered tissues. Here, cell-polymer constructs for engineered cartilage have been fabricated by seeding chondrocytes within three-dimensional scaffolds of biodegradable polymers. During culture, synthetic scaffolds degraded passively as the cells assembled an extracellular matrix (ECM) composed primarily of glycosaminoglycan (GAG) and collagen. During development, biochemical and biomechanical assessment of the composite (cells, ECM, and polymer scaffold) were modeled at a unit-cell level to predict their individual effect on the construct elastic properties (n = 4 samples per 7 time points). This approach employed a composite spheres, micromechanical analysis to determine bulk moduli of: 1) the cellular-ECM inclusion within the supporting scaffold structure; and 2) the cellular inclusion within its ECM. This analytical technique offers an interpretation of the constituent dynamics for cell-based tissue regeneration.

Original languageEnglish (US)
Title of host publicationProceedings of the 2005 SEM Annual Conference and Exposition on Experimental and Applied Mechanics
Pages375-380
Number of pages6
StatePublished - Dec 1 2005
Event2005 SEM Annual Conference and Exposition on Experimental and Applied Mechanics - Portland, OR, United States
Duration: Jun 7 2005Jun 9 2005

Publication series

NameProceedings of the 2005 SEM Annual Conference and Exposition on Experimental and Applied Mechanics

Other

Other2005 SEM Annual Conference and Exposition on Experimental and Applied Mechanics
CountryUnited States
CityPortland, OR
Period6/7/056/9/05

ASJC Scopus subject areas

  • Engineering(all)

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  • Cite this

    Kohles, S. S., Wilson, C. G., & Bonassar, L. J. (2005). A composite spheres analysis of engineered cartilage mechanics. In Proceedings of the 2005 SEM Annual Conference and Exposition on Experimental and Applied Mechanics (pp. 375-380). (Proceedings of the 2005 SEM Annual Conference and Exposition on Experimental and Applied Mechanics).