A common epitope on human myelin basic protein and the human T lymphocyte CD3 molecule

Z. Jingwu, W. E.J. Weber, J. Borst, A. A. Vandenbark, J. C.M. Raus

Research output: Contribution to journalArticle

7 Scopus citations

Abstract

In this report, we describe for the first time an epitope common to human myelin basic protein (H.MBP), a structural component of central nervous system myelin and T lymphocyte CD3, an activation molecule important in signal transduction. This cross-reactive determinant was recognized by a murine mAb WW.B1, which was raised against H.MBP. WW.B1 recognized PBMC and the Jurkat T leukemic cell line, immunoprecipitated both H.MBP and a complex indistinguishable from CD3, and possessed the same biologic properties - induction of T lymphocyte proliferation and inhibition of CTL function - as commercially available anti-CD3 antibodies. It is likely, however, that the epitope recognized by WW.B1 is distinct from those recognized by the anti-CD3 mAb OKT3 and anti-Leu-4. Although the biologic importance of this common determinant awaits further clarification, it is conceivable that autoimmunization to MBP could induce similar immunoregulatory antibody specificities.

Original languageEnglish (US)
Pages (from-to)3917-3922
Number of pages6
JournalJournal of Immunology
Volume142
Issue number11
StatePublished - 1989

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology

Fingerprint Dive into the research topics of 'A common epitope on human myelin basic protein and the human T lymphocyte CD3 molecule'. Together they form a unique fingerprint.

Cite this