A common epitope on human myelin basic protein and the human T lymphocyte CD3 molecule

Z. Jingwu, W. E J Weber, J. Borst, Arthur Vandenbark, J. C M Raus

Research output: Contribution to journalArticle

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Abstract

In this report, we describe for the first time an epitope common to human myelin basic protein (H.MBP), a structural component of central nervous system myelin and T lymphocyte CD3, an activation molecule important in signal transduction. This cross-reactive determinant was recognized by a murine mAb WW.B1, which was raised against H.MBP. WW.B1 recognized PBMC and the Jurkat T leukemic cell line, immunoprecipitated both H.MBP and a complex indistinguishable from CD3, and possessed the same biologic properties - induction of T lymphocyte proliferation and inhibition of CTL function - as commercially available anti-CD3 antibodies. It is likely, however, that the epitope recognized by WW.B1 is distinct from those recognized by the anti-CD3 mAb OKT3 and anti-Leu-4. Although the biologic importance of this common determinant awaits further clarification, it is conceivable that autoimmunization to MBP could induce similar immunoregulatory antibody specificities.

Original languageEnglish (US)
Pages (from-to)3917-3922
Number of pages6
JournalJournal of Immunology
Volume142
Issue number11
StatePublished - 1989
Externally publishedYes

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Epitopes
T-Lymphocytes
CD3 Antigens
Muromonab-CD3
Antibody Specificity
Lymphocyte Activation
Myelin Sheath
Anti-Idiotypic Antibodies
Signal Transduction
Central Nervous System
Cell Line
human MBP protein

ASJC Scopus subject areas

  • Immunology

Cite this

Jingwu, Z., Weber, W. E. J., Borst, J., Vandenbark, A., & Raus, J. C. M. (1989). A common epitope on human myelin basic protein and the human T lymphocyte CD3 molecule. Journal of Immunology, 142(11), 3917-3922.

A common epitope on human myelin basic protein and the human T lymphocyte CD3 molecule. / Jingwu, Z.; Weber, W. E J; Borst, J.; Vandenbark, Arthur; Raus, J. C M.

In: Journal of Immunology, Vol. 142, No. 11, 1989, p. 3917-3922.

Research output: Contribution to journalArticle

Jingwu, Z, Weber, WEJ, Borst, J, Vandenbark, A & Raus, JCM 1989, 'A common epitope on human myelin basic protein and the human T lymphocyte CD3 molecule', Journal of Immunology, vol. 142, no. 11, pp. 3917-3922.
Jingwu, Z. ; Weber, W. E J ; Borst, J. ; Vandenbark, Arthur ; Raus, J. C M. / A common epitope on human myelin basic protein and the human T lymphocyte CD3 molecule. In: Journal of Immunology. 1989 ; Vol. 142, No. 11. pp. 3917-3922.
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