TY - JOUR
T1 - A common epitope on human myelin basic protein and the human T lymphocyte CD3 molecule
AU - Jingwu, Z.
AU - Weber, W. E.J.
AU - Borst, J.
AU - Vandenbark, A. A.
AU - Raus, J. C.M.
PY - 1989
Y1 - 1989
N2 - In this report, we describe for the first time an epitope common to human myelin basic protein (H.MBP), a structural component of central nervous system myelin and T lymphocyte CD3, an activation molecule important in signal transduction. This cross-reactive determinant was recognized by a murine mAb WW.B1, which was raised against H.MBP. WW.B1 recognized PBMC and the Jurkat T leukemic cell line, immunoprecipitated both H.MBP and a complex indistinguishable from CD3, and possessed the same biologic properties - induction of T lymphocyte proliferation and inhibition of CTL function - as commercially available anti-CD3 antibodies. It is likely, however, that the epitope recognized by WW.B1 is distinct from those recognized by the anti-CD3 mAb OKT3 and anti-Leu-4. Although the biologic importance of this common determinant awaits further clarification, it is conceivable that autoimmunization to MBP could induce similar immunoregulatory antibody specificities.
AB - In this report, we describe for the first time an epitope common to human myelin basic protein (H.MBP), a structural component of central nervous system myelin and T lymphocyte CD3, an activation molecule important in signal transduction. This cross-reactive determinant was recognized by a murine mAb WW.B1, which was raised against H.MBP. WW.B1 recognized PBMC and the Jurkat T leukemic cell line, immunoprecipitated both H.MBP and a complex indistinguishable from CD3, and possessed the same biologic properties - induction of T lymphocyte proliferation and inhibition of CTL function - as commercially available anti-CD3 antibodies. It is likely, however, that the epitope recognized by WW.B1 is distinct from those recognized by the anti-CD3 mAb OKT3 and anti-Leu-4. Although the biologic importance of this common determinant awaits further clarification, it is conceivable that autoimmunization to MBP could induce similar immunoregulatory antibody specificities.
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M3 - Article
C2 - 2469727
AN - SCOPUS:0024317147
SN - 0022-1767
VL - 142
SP - 3917
EP - 3922
JO - Journal of Immunology
JF - Journal of Immunology
IS - 11
ER -