A Combined Sulbactam/Cefoperazone And Amikacin Therapy For The Treatment Of Infections Complicated With Hematological Deseases

Teruyuki Takashima, Shoichiro Tsuda, Shinichi Misawa, Shigeo Horiike, Yuko Kuzuyama, Kouichi Hirakawa, Hiroyuki Nakai, Taku Seriu, Shinji Tanaka, Kazuhiro Nishida, Masafumi Taniwaki, Kei Kashima, Hiroshi Fujii, Hitoshi Nakagawa, Tetsuro Nakai, Yasuo Ohkawara, Hitoshi Imanishi, Hikari Nishigaki, Shouhei Yokota

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3 Scopus citations

Abstract

Eightysix patients with infections associated with hematological disorders were treated with sulbactam/cefoperazone (SBT/CPZ) and amikacin (AMK). Among 71 evaluable cases, 30 cases had acute non-lymphocytic leukemia, 3 acute lymphoblastic leukemia, 25 malignant lymphoma, and 7 myelodysplastic syndrome as underlying diseases. Excellent responses were obtained in 33 cases (46.5%) and good responses in 14 cases (19.7%), with an overall efficacy rate of 66.2%. The efficacy rate among cases with suspected sepsis was 72.5%. This treatment was also effective in 69.2% of cases in which neutrophil counts were less than 500//A through the course of administration. The eradication rate was 83.3% among 6 strains in which Gram-negative rods were detected. Side effects were minimum; skin rash in 1 case, slight elevation of APTT in 3 and slight elevation of total bilirubin in 1. Thus, this combination antibacterial chemotherapy is an effective and safe regimen for the treatment of severe infections in patients with hematological disorders.

Original languageEnglish (US)
Pages (from-to)251-258
Number of pages8
JournalJapanese Journal of Antibiotics
Volume46
Issue number3
DOIs
StatePublished - Jan 1 1993

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ASJC Scopus subject areas

  • Microbiology (medical)
  • Pharmacology (medical)
  • Infectious Diseases

Cite this

Takashima, T., Tsuda, S., Misawa, S., Horiike, S., Kuzuyama, Y., Hirakawa, K., Nakai, H., Seriu, T., Tanaka, S., Nishida, K., Taniwaki, M., Kashima, K., Fujii, H., Nakagawa, H., Nakai, T., Ohkawara, Y., Imanishi, H., Nishigaki, H., & Yokota, S. (1993). A Combined Sulbactam/Cefoperazone And Amikacin Therapy For The Treatment Of Infections Complicated With Hematological Deseases. Japanese Journal of Antibiotics, 46(3), 251-258. https://doi.org/10.11553/antibiotics1968b.46.251