A Case of Myelodysplastic Syndrome in a Liver Transplant Patient

R. Potru, Joseph Ahn, H. Fung, S. M. Cohen

Research output: Contribution to journalArticle

Abstract

Although the incidence of (myelodysplastic syndrome (MDS)) is higher among heart and lung transplant recipients than the general population, the same has not been shown in liver transplant (OLT) patients. We present the second known case of MDS after OLT. Case reports of MDS in OLT were identified using PubMed. Patient data were gathered from the patient and the medical record. A 54-year-old Caucasian man underwent OLT in 2003 and again in 2004 for hepatitis C-related cirrhosis. In 2007, the patient developed weakness, malaise, and shortness of breath. Laboratory studies revealed pancytopenia. Bone marrow biopsy showed MDS, with refractory anemia and excess blasts-1. The patient underwent chemotherapy and reduction in immunosuppression without a clinical response. Our experience suggested that MDS, although rare, should be considered in the differential diagnosis of pancytopenia after OLT. Once diagnosed, immunosuppression reduction, chemotherapy, and even stem cell transplantation may be the appropriate treatment in selected candidates.

Original languageEnglish (US)
Pages (from-to)3947-3948
Number of pages2
JournalTransplantation Proceedings
Volume41
Issue number9
DOIs
StatePublished - Nov 2009
Externally publishedYes

Fingerprint

Myelodysplastic Syndromes
Transplants
Liver
Pancytopenia
Immunosuppression
Refractory Anemia with Excess of Blasts
Drug Therapy
Stem Cell Transplantation
Hepatitis C
PubMed
Dyspnea
Medical Records
Differential Diagnosis
Fibrosis
Bone Marrow
Biopsy
Lung
Incidence
Population

ASJC Scopus subject areas

  • Surgery
  • Transplantation

Cite this

A Case of Myelodysplastic Syndrome in a Liver Transplant Patient. / Potru, R.; Ahn, Joseph; Fung, H.; Cohen, S. M.

In: Transplantation Proceedings, Vol. 41, No. 9, 11.2009, p. 3947-3948.

Research output: Contribution to journalArticle

Potru, R. ; Ahn, Joseph ; Fung, H. ; Cohen, S. M. / A Case of Myelodysplastic Syndrome in a Liver Transplant Patient. In: Transplantation Proceedings. 2009 ; Vol. 41, No. 9. pp. 3947-3948.
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