A case-control study of twin pairs discordant for Parkinson’s disease: A search for environmental risk factors

Nadir E. Bharucha, Lynette Stokes, Bruce S. Schoenberg, Christopher Ward, Susan Ince, John G. Nutt, Roswell Eldridge, Donald B. Calne, Nathan Mantel, Roger Duvoisin

Research output: Contribution to journalArticle

80 Scopus citations

Abstract

A previous study of twins with Parkinson’s disease (PD) revealed low concordance, suggesting that genetic factors play a minor role in the etiology of PD. To identify possible environmental determinants of PD while maximally controlling for hereditary factors, 31 monozygotic twin pairs discordant for PD were interviewed by telephone. Information about possible risk factors was obtained from systematic and uniform interviews with cases and controls. The only statistically significant result was less cigarette smoking by PD patients (p < 0.05). Thirteen dizygotic discordant twin pairs were evaluated with the same techniques, but there were no statistically significant differences between affected and unaffected twins.

Original languageEnglish (US)
Pages (from-to)284-288
Number of pages5
JournalNeurology
Volume36
Issue number2
DOIs
StatePublished - Feb 1986

ASJC Scopus subject areas

  • Clinical Neurology

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    Bharucha, N. E., Stokes, L., Schoenberg, B. S., Ward, C., Ince, S., Nutt, J. G., Eldridge, R., Calne, D. B., Mantel, N., & Duvoisin, R. (1986). A case-control study of twin pairs discordant for Parkinson’s disease: A search for environmental risk factors. Neurology, 36(2), 284-288. https://doi.org/10.1212/wnl.36.2.284