A case-control study of twin pairs discordant for Parkinson’s disease: A search for environmental risk factors

Nadir E. Bharucha, Lynette Stokes, Bruce S. Schoenberg, Christopher Ward, Susan Ince, John Nutt, Roswell Eldridge, Donald B. Calne, Nathan Mantel, Roger Duvoisin

Research output: Contribution to journalArticle

80 Citations (Scopus)

Abstract

A previous study of twins with Parkinson’s disease (PD) revealed low concordance, suggesting that genetic factors play a minor role in the etiology of PD. To identify possible environmental determinants of PD while maximally controlling for hereditary factors, 31 monozygotic twin pairs discordant for PD were interviewed by telephone. Information about possible risk factors was obtained from systematic and uniform interviews with cases and controls. The only statistically significant result was less cigarette smoking by PD patients (p <0.05). Thirteen dizygotic discordant twin pairs were evaluated with the same techniques, but there were no statistically significant differences between affected and unaffected twins.

Original languageEnglish (US)
Pages (from-to)284-288
Number of pages5
JournalNeurology
Volume36
Issue number2
StatePublished - 1986

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Parkinson Disease
Case-Control Studies
Dizygotic Twins
Twin Studies
Monozygotic Twins
Telephone
Smoking
Environmental Risk
Parkinson's Disease
Risk Factors
Interviews

ASJC Scopus subject areas

  • Arts and Humanities (miscellaneous)
  • Clinical Neurology
  • Neuroscience(all)

Cite this

Bharucha, N. E., Stokes, L., Schoenberg, B. S., Ward, C., Ince, S., Nutt, J., ... Duvoisin, R. (1986). A case-control study of twin pairs discordant for Parkinson’s disease: A search for environmental risk factors. Neurology, 36(2), 284-288.

A case-control study of twin pairs discordant for Parkinson’s disease : A search for environmental risk factors. / Bharucha, Nadir E.; Stokes, Lynette; Schoenberg, Bruce S.; Ward, Christopher; Ince, Susan; Nutt, John; Eldridge, Roswell; Calne, Donald B.; Mantel, Nathan; Duvoisin, Roger.

In: Neurology, Vol. 36, No. 2, 1986, p. 284-288.

Research output: Contribution to journalArticle

Bharucha, NE, Stokes, L, Schoenberg, BS, Ward, C, Ince, S, Nutt, J, Eldridge, R, Calne, DB, Mantel, N & Duvoisin, R 1986, 'A case-control study of twin pairs discordant for Parkinson’s disease: A search for environmental risk factors', Neurology, vol. 36, no. 2, pp. 284-288.
Bharucha, Nadir E. ; Stokes, Lynette ; Schoenberg, Bruce S. ; Ward, Christopher ; Ince, Susan ; Nutt, John ; Eldridge, Roswell ; Calne, Donald B. ; Mantel, Nathan ; Duvoisin, Roger. / A case-control study of twin pairs discordant for Parkinson’s disease : A search for environmental risk factors. In: Neurology. 1986 ; Vol. 36, No. 2. pp. 284-288.
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