A canine model for studying laryngospasm and its prevention

Pamela S. Henderson; James I. Cohen; Per Olof Jarnberg; James D. Smith; Wendell Stevens

doi:10.1288/00005537-199211000-00006

A canine model for studying laryngospasm and its prevention

Pamela S. Henderson, James I. Cohen, Per Olof Jarnberg, James D. Smith, Wendell Stevens

Otolaryngology

Research output: Contribution to journal › Article › peer-review

5 Scopus citations

Abstract

Laryngospasm, if prolonged, can result in serious sequelae due to the lack of a uniformly effective treatment. Prevention, therefore, through pharmacologic intervention, is an attractive concept. In order to study the effects of various drugs in preventing laryngospasm, a reliable animal model capable of producing sequential, repetitive episodes of laryngospasm is necessary. In this study, the canine model of laryngospasm previously described by Aviv, et al. was modified to overcome technical factors which limited its use in this regard. Details of the technique and the results from eight animals will be presented. Results in two animals with the use of prophylactic topical lidocaine will also be discussed. The reliability and reproducibility of this model make it ideal for the study of laryngospasm and open the way for investigation into its prevention.

Original language	English (US)
Pages (from-to)	1237-1241
Number of pages	5
Journal	Laryngoscope
Volume	102
Issue number	11
DOIs	https://doi.org/10.1288/00005537-199211000-00006
State	Published - Nov 1992

ASJC Scopus subject areas

Otorhinolaryngology

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10.1288/00005537-199211000-00006

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title = "A canine model for studying laryngospasm and its prevention",

abstract = "Laryngospasm, if prolonged, can result in serious sequelae due to the lack of a uniformly effective treatment. Prevention, therefore, through pharmacologic intervention, is an attractive concept. In order to study the effects of various drugs in preventing laryngospasm, a reliable animal model capable of producing sequential, repetitive episodes of laryngospasm is necessary. In this study, the canine model of laryngospasm previously described by Aviv, et al. was modified to overcome technical factors which limited its use in this regard. Details of the technique and the results from eight animals will be presented. Results in two animals with the use of prophylactic topical lidocaine will also be discussed. The reliability and reproducibility of this model make it ideal for the study of laryngospasm and open the way for investigation into its prevention.",

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AU - Henderson, Pamela S.

AU - Cohen, James I.

AU - Jarnberg, Per Olof

AU - Smith, James D.

AU - Stevens, Wendell

PY - 1992/11

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N2 - Laryngospasm, if prolonged, can result in serious sequelae due to the lack of a uniformly effective treatment. Prevention, therefore, through pharmacologic intervention, is an attractive concept. In order to study the effects of various drugs in preventing laryngospasm, a reliable animal model capable of producing sequential, repetitive episodes of laryngospasm is necessary. In this study, the canine model of laryngospasm previously described by Aviv, et al. was modified to overcome technical factors which limited its use in this regard. Details of the technique and the results from eight animals will be presented. Results in two animals with the use of prophylactic topical lidocaine will also be discussed. The reliability and reproducibility of this model make it ideal for the study of laryngospasm and open the way for investigation into its prevention.

AB - Laryngospasm, if prolonged, can result in serious sequelae due to the lack of a uniformly effective treatment. Prevention, therefore, through pharmacologic intervention, is an attractive concept. In order to study the effects of various drugs in preventing laryngospasm, a reliable animal model capable of producing sequential, repetitive episodes of laryngospasm is necessary. In this study, the canine model of laryngospasm previously described by Aviv, et al. was modified to overcome technical factors which limited its use in this regard. Details of the technique and the results from eight animals will be presented. Results in two animals with the use of prophylactic topical lidocaine will also be discussed. The reliability and reproducibility of this model make it ideal for the study of laryngospasm and open the way for investigation into its prevention.

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A canine model for studying laryngospasm and its prevention

Abstract

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