A canine model for studying laryngospasm and its prevention

Pamela S. Henderson, James Cohen, Per-Olof Järnberg, James Smith, Wendell Stevens

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

Laryngospasm, if prolonged, can result in serious sequelae due to the lack of a uniformly effective treatment. Prevention, therefore, through pharmacologic intervention, is an attractive concept. In order to study the effects of various drugs in preventing laryngospasm, a reliable animal model capable of producing sequential, repetitive episodes of laryngospasm is necessary. In this study, the canine model of laryngospasm previously described by Aviv, et al. was modified to overcome technical factors which limited its use in this regard. Details of the technique and the results from eight animals will be presented. Results in two animals with the use of prophylactic topical lidocaine will also be discussed. The reliability and reproducibility of this model make it ideal for the study of laryngospasm and open the way for investigation into its prevention.

Original languageEnglish (US)
Pages (from-to)1237-1241
Number of pages5
JournalLaryngoscope
Volume102
Issue number11
StatePublished - 1992

Fingerprint

Laryngismus
Canidae
Lidocaine
Animal Models
Pharmaceutical Preparations

ASJC Scopus subject areas

  • Otorhinolaryngology

Cite this

Henderson, P. S., Cohen, J., Järnberg, P-O., Smith, J., & Stevens, W. (1992). A canine model for studying laryngospasm and its prevention. Laryngoscope, 102(11), 1237-1241.

A canine model for studying laryngospasm and its prevention. / Henderson, Pamela S.; Cohen, James; Järnberg, Per-Olof; Smith, James; Stevens, Wendell.

In: Laryngoscope, Vol. 102, No. 11, 1992, p. 1237-1241.

Research output: Contribution to journalArticle

Henderson, PS, Cohen, J, Järnberg, P-O, Smith, J & Stevens, W 1992, 'A canine model for studying laryngospasm and its prevention', Laryngoscope, vol. 102, no. 11, pp. 1237-1241.
Henderson PS, Cohen J, Järnberg P-O, Smith J, Stevens W. A canine model for studying laryngospasm and its prevention. Laryngoscope. 1992;102(11):1237-1241.
Henderson, Pamela S. ; Cohen, James ; Järnberg, Per-Olof ; Smith, James ; Stevens, Wendell. / A canine model for studying laryngospasm and its prevention. In: Laryngoscope. 1992 ; Vol. 102, No. 11. pp. 1237-1241.
@article{53d4c7d8ed264a02a5ac7a98e569a355,
title = "A canine model for studying laryngospasm and its prevention",
abstract = "Laryngospasm, if prolonged, can result in serious sequelae due to the lack of a uniformly effective treatment. Prevention, therefore, through pharmacologic intervention, is an attractive concept. In order to study the effects of various drugs in preventing laryngospasm, a reliable animal model capable of producing sequential, repetitive episodes of laryngospasm is necessary. In this study, the canine model of laryngospasm previously described by Aviv, et al. was modified to overcome technical factors which limited its use in this regard. Details of the technique and the results from eight animals will be presented. Results in two animals with the use of prophylactic topical lidocaine will also be discussed. The reliability and reproducibility of this model make it ideal for the study of laryngospasm and open the way for investigation into its prevention.",
author = "Henderson, {Pamela S.} and James Cohen and Per-Olof J{\"a}rnberg and James Smith and Wendell Stevens",
year = "1992",
language = "English (US)",
volume = "102",
pages = "1237--1241",
journal = "Laryngoscope",
issn = "0023-852X",
publisher = "John Wiley and Sons Inc.",
number = "11",

}

TY - JOUR

T1 - A canine model for studying laryngospasm and its prevention

AU - Henderson, Pamela S.

AU - Cohen, James

AU - Järnberg, Per-Olof

AU - Smith, James

AU - Stevens, Wendell

PY - 1992

Y1 - 1992

N2 - Laryngospasm, if prolonged, can result in serious sequelae due to the lack of a uniformly effective treatment. Prevention, therefore, through pharmacologic intervention, is an attractive concept. In order to study the effects of various drugs in preventing laryngospasm, a reliable animal model capable of producing sequential, repetitive episodes of laryngospasm is necessary. In this study, the canine model of laryngospasm previously described by Aviv, et al. was modified to overcome technical factors which limited its use in this regard. Details of the technique and the results from eight animals will be presented. Results in two animals with the use of prophylactic topical lidocaine will also be discussed. The reliability and reproducibility of this model make it ideal for the study of laryngospasm and open the way for investigation into its prevention.

AB - Laryngospasm, if prolonged, can result in serious sequelae due to the lack of a uniformly effective treatment. Prevention, therefore, through pharmacologic intervention, is an attractive concept. In order to study the effects of various drugs in preventing laryngospasm, a reliable animal model capable of producing sequential, repetitive episodes of laryngospasm is necessary. In this study, the canine model of laryngospasm previously described by Aviv, et al. was modified to overcome technical factors which limited its use in this regard. Details of the technique and the results from eight animals will be presented. Results in two animals with the use of prophylactic topical lidocaine will also be discussed. The reliability and reproducibility of this model make it ideal for the study of laryngospasm and open the way for investigation into its prevention.

UR - http://www.scopus.com/inward/record.url?scp=0026457523&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0026457523&partnerID=8YFLogxK

M3 - Article

C2 - 1405983

AN - SCOPUS:0026457523

VL - 102

SP - 1237

EP - 1241

JO - Laryngoscope

JF - Laryngoscope

SN - 0023-852X

IS - 11

ER -