5-HTTLPR genotype and gender, but not chronic fluoxetine administration, are associated with cortical TREK1 protein expression in rhesus macaques

R. Bogdan, H. Fitzgibbon, W. L. Woolverton, Cynthia Bethea, A. H. Iyo, C. A. Stockmeier, P. B. Kyle, M. C. Austin

    Research output: Contribution to journalArticle

    6 Citations (Scopus)

    Abstract

    TREK1 is a widely expressed background potassium channel. Similar to mice treated with selective serotonin reuptake inhibitors (SSRIs), TREK1 knockout mice are resistant to depression-like behavior and have elevated serotonin levels leading to speculation that TREK1 inhibition may contribute to the therapeutic effects of SSRIs. This study examined how chronic fluoxetine administration and a common functional polymorphism in the serotonin-transporter-linked promoter region (5-HTTLPR) influence cortical TREK1 expression in 24 rhesus monkeys. The short rh5-HTTLPR allele as well as female gender were associated with reduced cortical TREK1 protein expression but chronic SSRI administration had no effect. These results suggest that serotonin may influence TREK1, but that chronic SSRI treatment does not result in long lasting changes in cortical TREK1 protein expression. TREK1 gender differences may be related to gender differences in serotonin and require further research.

    Original languageEnglish (US)
    Pages (from-to)83-86
    Number of pages4
    JournalNeuroscience Letters
    Volume503
    Issue number2
    DOIs
    StatePublished - Oct 3 2011

    Fingerprint

    Fluoxetine
    Serotonin Uptake Inhibitors
    Macaca mulatta
    Genotype
    Serotonin
    Tandem Pore Domain Potassium Channels
    Serotonin Plasma Membrane Transport Proteins
    Therapeutic Uses
    Genetic Promoter Regions
    Knockout Mice
    Alleles
    Depression
    potassium channel protein TREK-1
    Research

    Keywords

    • 5-HTTLPR
    • Depression
    • Monkey
    • Rhesus macaques
    • Serotonin
    • SSRI
    • TREK1
    • Western blot

    ASJC Scopus subject areas

    • Neuroscience(all)

    Cite this

    5-HTTLPR genotype and gender, but not chronic fluoxetine administration, are associated with cortical TREK1 protein expression in rhesus macaques. / Bogdan, R.; Fitzgibbon, H.; Woolverton, W. L.; Bethea, Cynthia; Iyo, A. H.; Stockmeier, C. A.; Kyle, P. B.; Austin, M. C.

    In: Neuroscience Letters, Vol. 503, No. 2, 03.10.2011, p. 83-86.

    Research output: Contribution to journalArticle

    Bogdan, R. ; Fitzgibbon, H. ; Woolverton, W. L. ; Bethea, Cynthia ; Iyo, A. H. ; Stockmeier, C. A. ; Kyle, P. B. ; Austin, M. C. / 5-HTTLPR genotype and gender, but not chronic fluoxetine administration, are associated with cortical TREK1 protein expression in rhesus macaques. In: Neuroscience Letters. 2011 ; Vol. 503, No. 2. pp. 83-86.
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