3D printing: Prospects and challenges: Nanomaterials in 3D bioprinting: Current approaches and future possibilities

Greeshma Thrivikraman, Cristiane M. França, Avathamsa Athirasala, Anthony Tahayeri, Luiz Bertassoni

Research output: Chapter in Book/Report/Conference proceedingChapter

2 Citations (Scopus)

Abstract

Regenerative medicine is an emergent multidisciplinary field that aims to significantly improve tissue repair or restoration, thus focusing on tissue engineering (TE) in regenerative medicine is inevitable. TE has created a useful ground in which biomaterials science witnessed a huge jump in improving diagnosis and treatment during recent years. TE brings together relevant knowledge from physical sciences, molecular engineering, biotechnology, and medicine toward ameliorated regrowing of the damaged tissue when the body is not able to completely heal itself. three-dimensional (3D) printing comes as a branch of TE technologies, allowing the synthesis of 3D constructs that provide key physiological environments for cell growing. In addition, nanoengineered systems hold tremendous potential in regenerative medicine, as their properties can be fine-tuned to promote tighter communication between cells and implantable materials. In Subchapter 4.1, intelligent biomaterials, 3D printing-based technologies, and nanosystems for imaging and drug delivery are presented and discussed, with special emphasis to their current applications toward a sounding impact in regenerative medicine.While the use and applicability of nanotechnology is swiftly expanding in several areas of biomedical engineering, its utility has not been fully realized in 3D bioprinting. Nanostructured materials seem to have enormous potential in bioprinting, as even a small fraction of nanoparticle loading can remarkably enrich the printability of bioinks without affecting the viability of the encapsulated cells, and in many cases enhancing overall cell behavior, such as differentiation, proliferation, electrical conductivity, and so on. Additionally, nanomaterials enable easy surface modification with specific biochemical factors or cellular ligands to improve cell adhesion, signaling, and specific cell functions. Subchapter 4.2 provides a general introduction to the background and motivation of using nanomaterials in tissue engineering and regenerative medicine by means of 3D bioprinting. We provide an overview of the current literature on some of the frequently employed nanomaterials in developing hybrid bioinks for 3D bioprinting applications, and describe a range of bioink properties that can be enhanced by the inclusion of specific nanoparticles. In addition, we discuss potential toxicity issues that may arise from the use of nanofilled bioinks, while advocating thorough screening of nanomaterials to avoid undesirable or toxic side effects.

Original languageEnglish (US)
Title of host publicationNanotechnologies in Preventive and Regenerative Medicine
Subtitle of host publicationAn Emerging Big Picture
PublisherElsevier Inc.
Pages349-379
Number of pages31
ISBN (Electronic)9780323480642
ISBN (Print)9780323480635
DOIs
StatePublished - Nov 22 2017

Fingerprint

Bioprinting
Regenerative Medicine
Nanostructures
Tissue Engineering
Biocompatible Materials
Nanoparticles
Biomedical Engineering
Technology
Natural Science Disciplines
Electric Conductivity
Nanotechnology
Poisons
Biotechnology
Cell Adhesion
Cell Communication
Cell Survival
Medicine
Three Dimensional Printing
Ligands
Pharmaceutical Preparations

Keywords

  • 3D printing
  • Bioinks
  • Biomaterials
  • Bioprinting
  • Drug delivery
  • Hydrogels
  • Nanomaterials
  • Nanoparticles
  • Nanosystems
  • Regenerative medicine
  • Tissue engineering

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Thrivikraman, G., França, C. M., Athirasala, A., Tahayeri, A., & Bertassoni, L. (2017). 3D printing: Prospects and challenges: Nanomaterials in 3D bioprinting: Current approaches and future possibilities. In Nanotechnologies in Preventive and Regenerative Medicine: An Emerging Big Picture (pp. 349-379). Elsevier Inc.. https://doi.org/10.1016/B978-0-323-48063-5.00004-6

3D printing : Prospects and challenges: Nanomaterials in 3D bioprinting: Current approaches and future possibilities. / Thrivikraman, Greeshma; França, Cristiane M.; Athirasala, Avathamsa; Tahayeri, Anthony; Bertassoni, Luiz.

Nanotechnologies in Preventive and Regenerative Medicine: An Emerging Big Picture. Elsevier Inc., 2017. p. 349-379.

Research output: Chapter in Book/Report/Conference proceedingChapter

Thrivikraman, G, França, CM, Athirasala, A, Tahayeri, A & Bertassoni, L 2017, 3D printing: Prospects and challenges: Nanomaterials in 3D bioprinting: Current approaches and future possibilities. in Nanotechnologies in Preventive and Regenerative Medicine: An Emerging Big Picture. Elsevier Inc., pp. 349-379. https://doi.org/10.1016/B978-0-323-48063-5.00004-6
Thrivikraman G, França CM, Athirasala A, Tahayeri A, Bertassoni L. 3D printing: Prospects and challenges: Nanomaterials in 3D bioprinting: Current approaches and future possibilities. In Nanotechnologies in Preventive and Regenerative Medicine: An Emerging Big Picture. Elsevier Inc. 2017. p. 349-379 https://doi.org/10.1016/B978-0-323-48063-5.00004-6
Thrivikraman, Greeshma ; França, Cristiane M. ; Athirasala, Avathamsa ; Tahayeri, Anthony ; Bertassoni, Luiz. / 3D printing : Prospects and challenges: Nanomaterials in 3D bioprinting: Current approaches and future possibilities. Nanotechnologies in Preventive and Regenerative Medicine: An Emerging Big Picture. Elsevier Inc., 2017. pp. 349-379
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