β-Endorphin concentrations in serum, hypothalamus and central gray of hypophysectomized and mediobasal hypothalamus lesioned rats

Bernard Kerdelhué, Cynthia L. Bethea, Nicolas Ling, Michel Chrétien, Richard I. Weiner

    Research output: Contribution to journalArticle

    39 Scopus citations

    Abstract

    The serum and brain concentrations of β-endorphin immunoreactivity have been studied in intact, mediobasal hypothalamus (MBH) lesioned and hypophysectomized male rats. After hypophysectomy there is a major reduction (90%) of β-endorphin concentration in the serum but only a partial reduction (20%) in the mediobasal hypothalamus. However, MBH lesions enhance β-endorphin serum values in previously hypophysectomized rats. Long-term MBH lesions alone lead to an almost complete disappearance of β-endorphin in the central gray matter with a slight decrease in the serum. These data clearly show that: (1) the pituitary is the major source of β-endorphin in the serum; (2) the hypothalamus is the major source of β-endorphin in the central gray matter; and (3) there is clear influence of the pituitary on hypothalamic β-endorphin.

    Original languageEnglish (US)
    Pages (from-to)85-91
    Number of pages7
    JournalBrain research
    Volume231
    Issue number1
    DOIs
    StatePublished - Jan 7 1982

    Keywords

    • central gray
    • hypophysectomy
    • mediobasal hypothalamus
    • pituitary
    • β-endorphin

    ASJC Scopus subject areas

    • Neuroscience(all)
    • Molecular Biology
    • Clinical Neurology
    • Developmental Biology

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